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弧菌毒素

弧菌毒素用途

青霉毒素是从青霉中提取的一种新型真菌毒素,在大鼠体内的LD50为122.4 mg/kg。

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弧菌毒素名称

[ CAS 号 ]:
39277-41-3

[ 中文名 ]:
弧菌毒素

[ 英文名 ]:
Viridicatumtoxin

[英文别名 ]:

Virginiamycin butanolide D
virginiae butanolide D

弧菌毒素生物活性

[ 描述 ]:

青霉毒素是从青霉中提取的一种新型真菌毒素,在大鼠体内的LD50为122.4 mg/kg。

[ 相关类别 ]:

研究领域 >> 感染

[参考文献]

[1]. Hutchison RD, et al. Viridicatumtoxin, a new mycotoxin from Penicillium viridicatum Westling. Toxicol Appl Pharmacol. 1973;24(3):507-509.

弧菌毒素物理化学性质

[ 密度 ]:
1.64g/cm3

[ 沸点 ]:
711.8ºC at 760mmHg

[ 分子式 ]:
C₃₀H₃₁NO₁₀

[ 分子量 ]:
565.56800

[ 闪点 ]:
384.3ºC

[ 精确质量 ]:
565.19500

[ PSA ]:
207.84000

[ LogP ]:
2.48220

[ 折射率 ]:
1.771

弧菌毒素毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: ZA4930000

CHEMICAL NAME :: Viridicatumtoxin

CAS REGISTRY NUMBER :: 39277-41-3

LAST UPDATED :: 199612

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C30-H31-N-O10

MOLECULAR WEIGHT :: 565.62

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 122 mg/kg

TOXIC EFFECTS :: Cardiac - other changes Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Blood - changes in spleen

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 90 mg/kg

TOXIC EFFECTS :: Gastrointestinal - peritonitis Nutritional and Gross Metabolic - weight loss or decreased weight gain Nutritional and Gross Metabolic - dehydration

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 80 mg/kg

TOXIC EFFECTS :: Gastrointestinal - peritonitis Nutritional and Gross Metabolic - weight loss or decreased weight gain Nutritional and Gross Metabolic - dehydration

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 25 ug/plate

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 58,193,1978