鸟苷3',5'-环一磷酸钠盐(cGMP)

鸟苷3',5'-环一磷酸钠盐(cGMP)用途

环GMP钠(cGMP)是平滑肌张力短期变化和对慢性药物治疗或增殖信号的长期反应的重要调节因子,它是对心钠素(ANP)或一氧化氮(NO)的反应。环GMP钠与阳离子通道相互作用,以调节离子转运或激活环GMP依赖性蛋白激酶,从而导致蛋白磷酸化[1][2]。

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鸟苷3',5'-环一磷酸钠盐(cGMP)名称

[ CAS 号 ]:
40732-48-7

[ 中文名 ]:
鸟苷-3,5-环单磷酸单钠盐

[ 英文名 ]:
guanosine 3':5'-cyclic monophosphate sodium salt

[中文别名 ]:

[英文别名 ]:

Guanosine 3',5'-Cyclic Monophosphate Sodium Salt
EINECS 255-056-0
MFCD00038424

鸟苷3',5'-环一磷酸钠盐(cGMP)生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 炎症/免疫

[ 靶点 ]

Human Endogenous Metabolite

鸟苷3',5'-环一磷酸钠盐(cGMP)物理化学性质

[ 分子式 ]:
C₁₀H₁₁N₅NaO₇P

[ 分子量 ]:
367.187

[ 精确质量 ]:
367.029388

[ PSA ]:
187.45000

[ 外观性状 ]:
白色粉末/白色至灰白色固体

[ 储存条件 ]:
−20°C

[ 水溶解性 ]:
H2O: 50 mg/mL

鸟苷3',5'-环一磷酸钠盐(cGMP)安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
29349990

鸟苷3',5'-环一磷酸钠盐(cGMP)文献

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Oncotarget 6(9) , 6877-86, (2015)

High doses of the organic nitrate glyceryl trinitrate (GTN), a nitric oxide (NO) donor, are known to trigger apoptosis in human cancer cells. Here, we show that such a cytotoxic effect can be obtained...

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Am. J. Physiol. Cell Physiol. 308(7) , C557-69, (2015)

The biological effects of atrial natriuretic peptide (ANP) are mediated by natriuretic peptide receptors (NPRs), which can either activate guanylyl cyclase (NPRA and NPRB) or inhibit adenylyl cyclase ...

Safety, pharmacokinetics and neutralization of the broadly neutralizing HIV-1 human monoclonal antibody VRC01 in healthy adults.

Clin. Exp. Immunol. 182 , 289-301, (2015)

VRC-HIVMAB060-00-AB (VRC01) is a broadly neutralizing HIV-1 monoclonal antibody (mAb) isolated from the B cells of an HIV-infected patient. It is directed against the HIV-1 CD4 binding site and is cap...

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