异佛尔酮二异氰酸酯
异佛尔酮二异氰酸酯名称
[ CAS 号 ]:
4098-71-9
[ 中文名 ]:
异佛尔酮二异氰酸酯
[ 英文名 ]:
UNII:43B0856528
[中文别名 ]:
[英文别名 ]:
- Isophorone diisocyanate
- EINECS 223-861-6
- UNII:43B0856528
- MFCD00064956
- IPDI
异佛尔酮二异氰酸酯物理化学性质
[ 密度 ]:
1.1±0.1 g/cm3
[ 沸点 ]:
286.9±13.0 °C at 760 mmHg
[ 熔点 ]:
-60°C
[ 分子式 ]:
C12H18N2O2
[ 分子量 ]:
222.283
[ 闪点 ]:
116.0±25.2 °C
[ 精确质量 ]:
222.136826
[ PSA ]:
58.86000
[ LogP ]:
4.67
[ 外观性状 ]:
无色或略黄色液体
[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C
[ 折射率 ]:
1.520
[ 储存条件 ]:
库房通风低温干燥,与含水物品、醇类、胺类分开储运
[ 稳定性 ]:
Reacts with all substances containing active hydrogen, such as acids, amines, water, phenols, mercaptans, amides, urea. Probably moisture sensitive.
[ 水溶解性 ]:
<0.1 g/100 mL at 25 ºC
异佛尔酮二异氰酸酯MSDS
异佛尔酮二异氰酸酯毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- NQ9370000
- CHEMICAL NAME :
- Isocyanic acid, methylene(3,5,5-trimethyl-3,1-cyclohexylene) ester
- CAS REGISTRY NUMBER :
- 4098-71-9
- LAST UPDATED :
- 199712
- DATA ITEMS CITED :
- 24
- MOLECULAR FORMULA :
- C12-H18-N2-O2
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 4825 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0530238
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 123 mg/m3/4H
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 85INA8 "Documentation of the Threshold Limit Values and Biological Exposure Indices," 5th ed., Cincinnati, OH, American Conference of Governmental Industrial Hygienists, Inc., 1986 Volume(issue)/page/year: 5,334(86),1986
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1 mL/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0528418
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2500 uL/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0528418
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - cat
- DOSE/DURATION :
- 1 mL/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0528418
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 118 mg/m3/1H
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - weight loss or decreased weight gain
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0543418 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1370 ug/m3/4H/4W-I
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0528418 *** REVIEWS *** ACGIH TLV-TWA 0.045 mg/m3 (0.005 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-BELGIUM:TWA 0.005 ppm (0.045 mg/m3);Skin JAN 1993 OEL-DENMARK:TWA 0.005 ppm (0.045 mg/m3);Skin JAN 1993 OEL-FRANCE:TWA 0.010 ppm (0.09 mg/m3);STEL 0.020 ppm JAN 1993 OEL-GERMANY:TWA 0.01 ppm (0.09 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 0.01 ppm (0.09 mg/m3);Skin JAN 1993 OEL-SWEDEN:TWA 0.005 ppm (0.05 mg/m3);STEL 0.01 ppm (0.09 mg/m3) JAN 1993 OEL-SWITZERLAND:TWA 0.01 ppm (0.09 mg/m3);STEL 0.02 ppm JAN 1993 OEL-UNITED KINGDOM:TWA 0.02 mg/m3;STEL 0.07 mg/m3 JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO IPDI-air:10H TWA 0.005 ppm (Sk);STEL 0.02 ppm (Sk) REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83571 No. of Facilities: 111 (estimated) No. of Industries: 4 No. of Occupations: 19 No. of Employees: 3441 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83571 No. of Facilities: 1186 (estimated) No. of Industries: 15 No. of Occupations: 16 No. of Employees: 7245 (estimated) No. of Female Employees: 682 (estimated)
异佛尔酮二异氰酸酯安全信息
[ 符号 ]:
GHS06, GHS08, GHS09
[ 信号词 ]:
Danger
[ 危害声明 ]:
H315-H317-H319-H330-H334-H335-H411
[ 警示性声明 ]:
P260-P280-P284-P304 + P340 + P310-P342 + P311-P403 + P233
[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ 危害码 (欧洲) ]:
T:Toxic;N:Dangerousfortheenvironment;
[ 风险声明 (欧洲) ]:
R22;R36/37/38;R42/43;R51/53
[ 安全声明 (欧洲) ]:
S26-S28-S38-S45-S61
[ 危险品运输编码 ]:
UN 2290 6.1/PG 3
[ WGK德国 ]:
2
[ RTECS号 ]:
NQ9370000
[ 包装等级 ]:
III
[ 危险类别 ]:
6.1
[ 海关编码 ]:
2929109000
异佛尔酮二异氰酸酯上下游产品
异佛尔酮二异氰酸酯上游产品
异佛尔酮二异氰酸酯下游产品
异佛尔酮二异氰酸酯海关
[ 海关编码 ]: 2929109000
[ 中文概述 ]:
2929109000. 其他异氰酸酯. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
[ 申报要素 ]: 品名, 成分含量, 用途
[ Summary ]:
2929109000. other isocyanates. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%
异佛尔酮二异氰酸酯文献
Acta Biomater. 28 , 55-63, (2015)
Gene delivery into cells can be facilitated by adding plasmid DNA/transfection reagent complexes in culture medium or pre-adsorbing the complexes on the substrate before cell seeding. Using transfecti...
Modelling the surface free energy parameters of polyurethane coats-part 1. Solvent-based coats obtained from linear polyurethane elastomers.Colloid Polym. Sci. 291(4) , 1031-1047, (2013)
Polyurethane elastomers coating were synthesised by using typical diisocyanates, polyether and polyester polyols and HO-tertiary amines or diols as a chain extenders. Mole fractions of structural frag...
Polyurethane Microstructures--a Good or Bad in vitro Partner for the Isoflavone Genistein?Nat. Prod. Commun. 10 , 951-4, (2015)
In recent years polyurethane microstructures (PM) have gained increasing attention in the pharmaceutical field due to the importance of their practical application. Since finding that such a formulati...
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