Fluocortin butyl ester

Fluocortin butyl ester用途

氟考替丁丁酯是一种开发的皮质类固醇化合物,局部使用时没有检测到全身皮质类固醇活性。氟考替丁丁酯似乎是一种有效且耐受性良好的局部类固醇,可用于常年性鼻炎的研究[1]。
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Fluocortin butyl ester名称

[ CAS 号 ]:
41767-29-7

[ 英文名 ]:
Fluocortin butyl ester

[英文别名 ]:

Fluocortin butyl ester生物活性

[ 描述 ]:

氟考替丁丁酯是一种开发的皮质类固醇化合物,局部使用时没有检测到全身皮质类固醇活性。氟考替丁丁酯似乎是一种有效且耐受性良好的局部类固醇,可用于常年性鼻炎的研究[1]。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他
研究领域 >> 炎症/免疫

[体内研究]

即使重复皮下注射或口服剂量高达100 mg/kg的氟考替丁丁酯,也不会降低动物对微生物感染的抵抗力【2】。

[参考文献]

[1]. Hartley TF, et al. Efficacy and tolerance of fluocortin butyl administered twice daily in adult patients with perennial rhinitis. J Allergy Clin Immunol. 1985;75(4):501-507.

[2]. [2] Kessler HJ et al. Tierexperimentelle Untersuchungen über den Einfluss von Fluocortin-butylester auf den Verlauf generalisierter Infektionen [Experimental studies in animals on the influence of fluocortin butylester on the course of generalized infections (author's transl)]. Arzneimittelforschung. 1977;27(11a):2214-2216.

Fluocortin butyl ester物理化学性质

[ 分子式 ]:
C26H35FO5

[ 分子量 ]:
446.55

[ 精确质量 ]:
446.24700

[ PSA ]:
80.67000

[ LogP ]:
3.98770

Fluocortin butyl ester毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TU4155000
CHEMICAL NAME :
Pregna-1,4-dien-21-oic acid, 6-fluoro-11-hydroxy-16-methyl-3,20-dioxo-, butyl ester, (6-alpha,11-beta,16-alpha)-
CAS REGISTRY NUMBER :
41767-29-7
LAST UPDATED :
199103
DATA ITEMS CITED :
7
MOLECULAR FORMULA :
C26-H35-F-O5
MOLECULAR WEIGHT :
446.61
WISWESSER LINE NOTATION :
L E5 B666 CV OV AHTTT&J A1 E1 FVVO4 G1 LF

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>4 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,2217,1977
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>4 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,2217,1977
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>4 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,2217,1977
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,2217,1977
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2700 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,2217,1977
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,2217,1977
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
>1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,2217,1977
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