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苏丹黑B

苏丹黑B用途

苏丹黑B是一种脂溶性重氮染料,是一种组织化学染色剂。苏丹黑B可用于中性甘油三酯和脂质染色[1]。

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苏丹黑B名称

[ CAS 号 ]:
4197-25-5

[ 中文名 ]:
溶剂黑 3

[ 英文名 ]:
Solvent Black 3

[中文别名 ]:

[英文别名 ]:

MFCD00006919
Sudan Black B,high purity biological stain
Fat Black HB
Sudan Black B,certified
SOLVENT BLACK 3
Ceres Black BN
EINECS 224-087-1
Sudan Black B

苏丹黑B生物活性

[ 描述 ]:

苏丹黑B是一种脂溶性重氮染料,是一种组织化学染色剂。苏丹黑B可用于中性甘油三酯和脂质染色[1]。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[体外研究]

苏丹黑B在冷冻材料中也有效,因此在研究衰老时可以与SA-β-半乳糖互补使用。苏丹黑B是一种高度亲脂性的药剂,对脂褐素的脂质室具有高度的粘附性。在光镜下,苏丹红B-脂褐素阳性反应显示细胞和冷冻组织中有蓝黑色的细胞内颗粒,FFPE组织中有棕黑色颗粒。

[参考文献]

[1]. Konstantinos Evangelou, et al. Sudan Black B, The Specific Histochemical Stain for Lipofuscin: A Novel Method to Detect Senescent Cells. Methods Mol Biol. 2017;1534:111-119.

苏丹黑B物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
726.0±60.0 °C at 760 mmHg

[ 熔点 ]:
120-124 °C(lit.)

[ 分子式 ]:
C₂₉H₂₄N₆

[ 分子量 ]:
456.541

[ 闪点 ]:
392.9±32.9 °C

[ 精确质量 ]:
456.206238

[ PSA ]:
73.50000

[ LogP ]:
7.51

[ 外观性状 ]:
暗棕色至黑色粉末

[ 蒸汽压 ]:
0.0±2.4 mmHg at 25°C

[ 折射率 ]:
1.702

[ 储存条件 ]:
Store at RT.

苏丹黑BMSDS

详细MSDS(安全技术说明书)

苏丹黑B毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SD4431500

CHEMICAL NAME :: 1H-Perimidine, 2,3-dihydro-2,2-dimethyl-6-((4-(phenylazo)-1-naphthyl )azo)-

CAS REGISTRY NUMBER :: 4197-25-5

LAST UPDATED :: 199712

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C29-H24-N6

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 63 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#04918 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M2167 No. of Facilities: 601 (estimated) No. of Industries: 10 No. of Occupations: 10 No. of Employees: 4471 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M2167 No. of Facilities: 1141 (estimated) No. of Industries: 15 No. of Occupations: 24 No. of Employees: 19262 (estimated) No. of Female Employees: 13466 (estimated)

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苏丹黑B安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
F: Flammable;Xi: Irritant;

[ 风险声明 (欧洲) ]:
11-36/37/38

[ 安全声明 (欧洲) ]:
S24/25-S16

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
SD4431500

[ 海关编码 ]:
32041900

苏丹黑B海关

[ 海关编码 ]: 32041900

苏丹黑B文献

Tissue inhibitor of metalloproteinase-1 moderates airway re-epithelialization by regulating matrilysin activity.

Am. J. Pathol. 172(5) , 1256-70, (2008)

Obliterative bronchiolitis (OB) is the histopathological finding in chronic lung allograft rejection. Mounting evidence suggests that epithelial damage drives the development of airway fibrosis in OB....

Analysis and testing of biological stains--the Biological Stain Commission Procedures.

Biotech. Histochem. 77(5&6) , 237-275, (2002)

Improving fluorescence imaging of biological cells on biomedical polymers.

Acta Biomater. 7(4) , 1588-98, (2011)

Immunofluorescence imaging on polymeric biomaterials is often inhibited by autofluorescence and other optical phenomena. This often limits the analysis that can be performed on cells that are in conta...

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