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Notomycin A1

Notomycin A1用途

Coumermycin A1 是一种 JAK2 信号激活剂。Coumermycin A1 抑制 DNA 旋转酶 (b>DNA Gyrase),从而抑制细菌的细胞分裂。

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Notomycin A1名称

[ CAS 号 ]:
4434-05-3

[ 中文名 ]:
香豆霉素

[ 英文名 ]:
COUMERMYCIN AL

[中文别名 ]:

[英文别名 ]:

coumamycin
l)oxy)-4-hydroxy-8-methylcoumarin)
Sugordomycin D-la
Coumermycin
Cumamycin
coumermycins
notomycina1
COUMERMYCIN A1
Notomycin

Notomycin A1生物活性

[ 描述 ]:

Coumermycin A1 是一种 JAK2 信号激活剂。Coumermycin A1 抑制 DNA 旋转酶 (b>DNA Gyrase),从而抑制细菌的细胞分裂。

[ 相关类别 ]:

研究领域 >> 代谢疾病

信号通路 >> 抗感染 >> 细菌

[体外研究]

古霉素A1诱导的JAK2信号激活增加了SCOS2的mRNA水平,但降低了瘦素受体的mRNA水平[1]。

[参考文献]

[1]. Tiantian Zhang, et al. SOCS2 Inhibits Mitochondrial Fatty Acid Oxidation via Suppressing LepR/JAK2/AMPK Signaling Pathway in Mouse Adipocytes. Research Article.

Notomycin A1物理化学性质

[ 分子式 ]:
C₅₅H₅₉N₅O₂₀

[ 分子量 ]:
1110.08000

[ 精确质量 ]:
1109.38000

[ PSA ]:
354.89000

[ LogP ]:
5.71790

[ 外观性状 ]:
固体

[ 储存条件 ]:
2-8°C，密封，干燥

Notomycin A1毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UX9375000

CHEMICAL NAME :: Pyrrole-2-carboxylic acid, 5-methyl-, diester with 3,3'-((3-methylpyrrole-2,4-diyl) bis(carbonylimino))bis(7-((5,5-di-C-methyl-4-O-methyl -alpha-L-lyxopyranosy l)oxy)-4-hydroxy -8-methylcoumarin)

CAS REGISTRY NUMBER :: 4434-05-3

LAST UPDATED :: 199612

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C55-H59-N5-O20

MOLECULAR WEIGHT :: 1110.19

WISWESSER LINE NOTATION :: T66 BOVJ EQ J1 IO- FT6OTJ B1 B1 CO1 EQ DOV- BT5MJ E1&& DMV- DT5M BUTJ C1 BVM- DT66 BOVJ EQ J1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 159 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 25 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Escherichia coli

DOSE/DURATION :: 200 mg/L

REFERENCE :: NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 271,385,1978

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Notomycin A1安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
22

[ 安全声明 (欧洲) ]:
36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
UX9375000

Notomycin A1合成路线

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Notomycin A1文献

Multiplexing interactions to control antibiotic release from cyclodextrin hydrogels.

Macromol. Biosci. 11(11) , 1544-52, (2011)

A new strategy for affinity-based drug delivery by modification of the drug rather than modification of the device is presented. Rifampin is modified to contain either one or two PEG-adamantane arms, ...

Aminocoumarins inhibit osteoclast differentiation and bone resorption via downregulation of nuclear factor of activated T cells c1.

Biochem. Pharmacol. 85(3) , 417-25, (2013)

Aminocoumarins, such as coumermycin A1 and novobiocin, are natural products of streptomycetes. They are potent inhibitors of bacterial DNA gyrase and are used to suppress the growth of bacteria in inf...

Modulation of chaperone function and cochaperone interaction by novobiocin in the C-terminal domain of Hsp90: evidence that coumarin antibiotics disrupt Hsp90 dimerization.

J. Biol. Chem. 281 , 7161-7171, (2006)

The C-terminal domain of Hsp90 displays independent chaperone activity, mediates dimerization, and contains the MEEVD motif essential for interaction with tetratricopeptide repeat-containing immunophi...

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