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EBPC

EBPC用途

EBPC是一种有效的选择性醛糖还原酶抑制剂,IC50为47 nM【1】。

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EBPC名称

[ CAS 号 ]:
4450-98-0

[ 英文名 ]:
EBPC

[英文别名 ]:

1-Ebpc

EBPC生物活性

[ 描述 ]:

EBPC是一种有效的选择性醛糖还原酶抑制剂,IC50为47 nM【1】。

[ 相关类别 ]:

信号通路 >> 代谢酶/蛋白酶 >> 醛糖还原酶

研究领域 >> 代谢疾病

[参考文献]

[1]. Mylari BL, et al. A highly specific aldose reductase inhibitor, ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate, and its congeners. J Med Chem. 1991 Mar;34(3):1011-8.

EBPC物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
479.8±45.0 °C at 760 mmHg

[ 分子式 ]:
C₁₄H₁₅NO₄

[ 分子量 ]:
261.27

[ 闪点 ]:
244.0±28.7 °C

[ 精确质量 ]:
261.100098

[ PSA ]:
66.84000

[ LogP ]:
1.34

[ 蒸汽压 ]:
0.0±1.3 mmHg at 25°C

[ 折射率 ]:
1.615

[ 储存条件 ]:
-20°C，密闭，干燥

EBPCMSDS

EBPC安全信息

[ 符号 ]:

GHS05, GHS07

[ 信号词 ]:
Danger

[ 危害声明 ]:
H302-H318

[ 警示性声明 ]:
P280-P305 + P351 + P338

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2933990090

EBPC合成路线

EBPC上下游产品

EBPC上游产品

EBPC下游产品

EBPC海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

EBPC文献

The Prostaglandin F Synthase Activity of the Human Aldose Reductase AKR1B1 Brings New Lenses to Look at Pathologic Conditions.

Front. Pharmacol. 3 , 98, (2012)

Prostaglandins are important regulators of female reproductive functions to which aldose reductases exhibiting hydroxysteroid dehydrogenase activity also contribute. Our work on the regulation of repr...

Phorbol ester up-regulates aldose reductase expression in A549 cells: a potential role for aldose reductase in cell cycle modulation.

Cell. Mol. Life Sci. 62(10) , 1146-55, (2005)

Over-expression of aldose reductase (AR) has been observed in many cancer cells. To clarify the role of AR in tumor cells, we investigated the pathways mediating expression of the AR gene induced by 1...

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