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2-氟-4-甲基苯胺

2-氟-4-甲基苯胺名称

[ CAS 号 ]:
452-80-2

[ 中文名 ]:
2-氟-4-甲基苯胺

[ 英文名 ]:
2-fluoro-4-methyl-aniline

[中文别名 ]:

[英文别名 ]:

4-Amino-3-fluorotoluene
Benzenamine, 2-fluoro-4-methyl-
p-Toluidine, 2-fluoro-
2-Fluoro-4-methylaniline
Aniline, 2-fluoro-4-methyl-
2-Fluoro-4-methyaniline
ZR BF D1
MFCD00040975
EINECS 259-564-3
2-Fluoro-4-methylbenzenamine

2-氟-4-甲基苯胺物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
196.5±0.0 °C at 760 mmHg

[ 熔点 ]:
3 °C

[ 分子式 ]:
C₇H₈FN

[ 分子量 ]:
125.144

[ 闪点 ]:
79.4±0.0 °C

[ 精确质量 ]:
125.064079

[ PSA ]:
26.02000

[ LogP ]:
1.73

[ 外观性状 ]:
淡橙色液体

[ 蒸汽压 ]:
0.4±0.3 mmHg at 25°C

[ 折射率 ]:
1.542

[ 储存条件 ]:
室温

2-氟-4-甲基苯胺MSDS

2-氟-4-甲基苯胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XU6650000

CHEMICAL NAME :: p-Toluidine, 2-fluoro-

CAS REGISTRY NUMBER :: 452-80-2

BEILSTEIN REFERENCE NO. :: 2637578

LAST UPDATED :: 199707

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C7-H8-F-N

MOLECULAR WEIGHT :: 125.16

WISWESSER LINE NOTATION :: ZR BF D1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - wild bird species

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 21,315,1972

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2-氟-4-甲基苯胺安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301-H311-H315-H319-H331-H335

[ 警示性声明 ]:
P261-P280-P301 + P310-P305 + P351 + P338-P311

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
T:Toxic;

[ 风险声明 (欧洲) ]:
R23/24/25;R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36/37/39-S45

[ 危险品运输编码 ]:
UN 2810 6.1/PG 3

[ WGK德国 ]:
3

[ RTECS号 ]:
XU6650000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1

[ 海关编码 ]:
2921430090

2-氟-4-甲基苯胺合成路线

2-氟-4-甲基苯胺上下游产品

2-氟-4-甲基苯胺上游产品

2-氟-4-甲基苯胺下游产品

2-氟-4-甲基苯胺海关

[ 海关编码 ]: 2921430090

[ 中文概述 ]:
2921430090 甲苯胺及其衍生物以及它们的盐. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 原产地证据文件及编号(例附原产地证书, 原产于欧盟的

[ Summary ]:
HS:2921430090 toluidines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

2-氟-4-甲基苯胺文献

Synthesis of chiral building blocks for use in drug discovery.

Molecules 9(6) , 405-26, (2004)

In the past decade there has been a significant growth in the sales of pharmaceutical drugs worldwide, but more importantly there has been a dramatic growth in the sales of single enantiomer drugs. Th...

Rat liver microsomal metabolism of 2-halogenated 4-methylanilines.

Xenobiotica 22(12) , 1403-23, (1992)

1. Rat liver microsomal metabolism of 2-fluoro-, 2-chloro- and 2-bromo-4-methylaniline was investigated using h.p.l.c. Metabolites identified include products from side-chain C-hydroxylation (benzyl a...

Indoline derivatives as 5-HT(2C) receptor agonists.

Bioorg. Med. Chem. Lett. 14 , 2367-2370, (2004)

A series of 1-(1-indolinyl)-2-propylamines was synthesised and evaluated as 5-HT(2C) receptor agonists for the treatment of obesity. The general methods of synthesis of the precursor indoles are descr...

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