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2-氯-4'-氟苯乙酮

2-氯-4'-氟苯乙酮用途

用作医药中间体

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2-氯-4'-氟苯乙酮名称

[ CAS 号 ]:
456-04-2

[ 中文名 ]:
2-氯代-4'-氟苯乙酮

[ 英文名 ]:
4-Fluorophenacyl chloride

[中文别名 ]:

[英文别名 ]:

α-Chloro-p-fluoroacetophenone
G1VR DF
α-Chloro-para-fluoroacetophenone
2-chloro-4'-fluoro-acetophenone
α-Chloro-4'-fluoroacetophenone
A-CHLORO-4-FLUOROACETOPHENONE
p-Fluorophenacyl chloride
Fluorophenacylchloride
MFCD00011652
2-Chloro-4′-fluoroacetophenone

2-氯-4'-氟苯乙酮物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
247.0±15.0 °C at 760 mmHg

[ 熔点 ]:
47-50 °C(lit.)

[ 分子式 ]:
C₈H₆ClFO

[ 分子量 ]:
172.584

[ 闪点 ]:
103.2±20.4 °C

[ 精确质量 ]:
172.009125

[ PSA ]:
17.07000

[ LogP ]:
1.90

[ 外观性状 ]:
黄色-米色晶体

[ 蒸汽压 ]:
0.0±0.5 mmHg at 25°C

[ 折射率 ]:
1.514

[ 储存条件 ]:
室温

2-氯-4'-氟苯乙酮MSDS

详细MSDS(安全技术说明书)

2-氯-4'-氟苯乙酮毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AM6550000

CHEMICAL NAME :: Acetophenone, 2-chloro-4'-fluoro-

CAS REGISTRY NUMBER :: 456-04-2

BEILSTEIN REFERENCE NO. :: 0637860

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C8-H6-Cl-F-O

MOLECULAR WEIGHT :: 172.59

WISWESSER LINE NOTATION :: G1VR DF

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 89 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#05172

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2-氯-4'-氟苯乙酮安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
T:Toxic;Xi:Irritant;

[ 风险声明 (欧洲) ]:
R23/25;R34;R36/37/38

[ 安全声明 (欧洲) ]:
S26-S28-S45-S36/37/39

[ 危险品运输编码 ]:
UN 3261 8/PG 2

[ WGK德国 ]:
3

[ RTECS号 ]:
AM6550000

[ 包装等级 ]:
II

[ 危险类别 ]:
8

[ 海关编码 ]:
2914700090

2-氯-4'-氟苯乙酮上下游产品

2-氯-4'-氟苯乙酮上游产品

2-氯-4'-氟苯乙酮下游产品

2-氯-4'-氟苯乙酮海关

[ 海关编码 ]: 2914700090

[ 中文概述 ]:
2914700090 其他酮及醌的卤化、磺化衍生物（包括硝化和亚硝化衍生物）. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:5.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 丙酮报明包装

[ Summary ]:
HS: 2914700090 halogenated, sulphonated, nitrated or nitrosated derivatives of ketones and quinones, whether or not with other oxygen function Tax rebate rate:9.0% Supervision conditions:none VAT:17.0% MFN tariff:5.5% General tariff:30.0%

2-氯-4'-氟苯乙酮文献

Glutathione transferase omega 1 catalyzes the reduction of S-(phenacyl)glutathiones to acetophenones.

Chem. Res. Toxicol. 20(1) , 149-54, (2007)

S-(Phenacyl)glutathione reductase (SPG-R) plays a significant role in the biotransformation of reactive alpha-haloketones to nontoxic acetophenones. Comparison of the apparent subunit size, amino acid...

Synthesis and evaluation of ligands for D2-like receptors: the role of common pharmacophoric groups.

Bioorg. Med. Chem. 17(4) , 1716-23, (2009)

Arylcycloalkylamines, such as phenyl piperidines and piperazines and their arylalkyl substituents, constitute pharmacophoric groups exemplified in several antipsychotic agents. A review of previous re...

Allergic contact dermatitis from 3-(alpha-methoxy) methylenebenzofuran-2(3H)-one (MBF) and alpha-chloro-4-fluoroacetophenone (CFAP) in chemical process workers.

Contact Dermatitis 34(6) , 434-5, (1996)

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