氯乙酰氯

氯乙酰氯用途

用途1：主要用作医药及农药的原料，尤其用于丁草胺、甲草胺等除草剂的生产。
用途2：用于制备氨基酸和其他有机化合物。
用途3：用于农药乐果、氟乙酰胺、医药、溶剂、致冷剂、灭火剂、助染剂、润滑油添加剂等的生产。
用途4：用于医药、农药，也可用作萃取溶剂、制冷剂、助染剂和润滑油添加剂等。
用途5：有机合成。制造氯苯乙酮(催泪气)，制备氨基酸。

点击显示

氯乙酰氯名称

[ CAS 号 ]:
79-04-9

[ 中文名 ]:
一氯代乙酰氯

[ 英文名 ]:
Chloroacetyl chloride

[中文别名 ]:

[英文别名 ]:

MFCD00000725
CHLOROACETYL CHLORIDE FOR PHARMA SYNTHESIS
CHLORO ACETYL CHLORIDE
Chloroacetylchloride
EINECS 201-171-6
ACETYL CHLORIDE,2-CHLORO-
CHLORACETYLCHLORIDE
CHLORACETYL CHLORIDE
CHLORO ACETYL CHLORIDE (CAC)
CHLOROACETIC CHLORIDE

氯乙酰氯物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
106.0±0.0 °C at 760 mmHg

[ 熔点 ]:
−22 °C(lit.)

[ 分子式 ]:
C₂H₂Cl₂O

[ 分子量 ]:
112.943

[ 闪点 ]:
34.0±20.2 °C

[ 精确质量 ]:
111.948273

[ PSA ]:
17.07000

[ LogP ]:
0.69

[ 外观性状 ]:
透明液体

[ 蒸汽密度 ]:
3.9 (vs air)

[ 蒸汽压 ]:
28.8±0.2 mmHg at 25°C

[ 折射率 ]:
1.430

[ 储存条件 ]:
库房通风低温干燥,与H发孔剂、碱类、氰化物分开存放

[ 稳定性 ]:
Stable. Incompatible with strong bases, alcohols, strong oxidizing agents. May react violently on exposure to water or moisture.

[ 水溶解性 ]:
reacts

[ 凝固点 ]:
-22.5℃

氯乙酰氯MSDS

氯乙酰氯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AO6475000

CHEMICAL NAME :: Acetyl chloride, chloro-

CAS REGISTRY NUMBER :: 79-04-9

BEILSTEIN REFERENCE NO. :: 0605439

LAST UPDATED :: 199712

DATA ITEMS CITED :: 27

MOLECULAR FORMULA :: C2-H2-Cl2-O

MOLECULAR WEIGHT :: 112.94

WISWESSER LINE NOTATION :: GV1G

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 208 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85INA8 "Documentation of the Threshold Limit Values and Biological Exposure Indices," 5th ed., Cincinnati, OH, American Conference of Governmental Industrial Hygienists, Inc., 1986 Volume(issue)/page/year: 5,123(89),1986

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1000 ppm/4H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969 Volume(issue)/page/year: -,607,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 662 mg/kg

TOXIC EFFECTS :: Skin and Appendages - corrosive (after topical exposure)

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 54(2),90,1989

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 220 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 54(2),90,1989

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1300 ppm/2H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85INA8 "Documentation of the Threshold Limit Values and Biological Exposure Indices," 5th ed., Cincinnati, OH, American Conference of Governmental Industrial Hygienists, Inc., 1986 Volume(issue)/page/year: 5,123(89),1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 32 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#04538

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 316 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85INA8 "Documentation of the Threshold Limit Values and Biological Exposure Indices," 5th ed., Cincinnati, OH, American Conference of Governmental Industrial Hygienists, Inc., 1986 Volume(issue)/page/year: 5,123(89),1986 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1 ppm/6H/4W-I

TOXIC EFFECTS :: Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Behavioral - somnolence (general depressed activity) Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0536493

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5 ppm/6H/4W-I

TOXIC EFFECTS :: Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0536493

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - hamster

DOSE/DURATION :: 5 ppm/6H/4W-I

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0536493 *** REVIEWS *** ACGIH TLV-STEL 0.69 mg/m3 (0.15 ppm) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 0.23 mg/m3 (0.05 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 0.05 ppm (0.2 mg/m3) JAN 1993 OEL-BELGIUM:TWA 0.05 ppm (0.23 mg/m3) JAN 1993 OEL-DENMARK:TWA 0.05 ppm (0.2 mg/m3) JAN 1993 OEL-FRANCE:TWA 0.05 ppm (0.2 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 0.05 ppm (0.2 mg/m3) JAN 1993 OEL-RUSSIA:STEL 0.3 mg/m3;Skin JAN 1993 OEL-SWITZERLAND:TWA 0.05 ppm (0.24 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 0.05 ppm (0.2 mg/m3) JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO CHLOROACETYL CHLORIDE-air:10H TWA 0.05 ppm REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - A1131 No. of Facilities: 33 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 66 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - A1131 No. of Facilities: 21 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 4354 (estimated) No. of Female Employees: 729 (estimated)

点击显示

氯乙酰氯安全信息

[ 符号 ]:

GHS05, GHS06, GHS08, GHS09

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301 + H311 + H331-H314-H372-H400

[ 补充危害声明 ]:
Contact with water liberates toxic gas., Reacts violently with water.

[ 警示性声明 ]:
P261-P273-P280-P301 + P310-P305 + P351 + P338-P310

[ 个人防护装备 ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
C:Corrosive

[ 风险声明 (欧洲) ]:
R14;R23/24/25;R35;R48/23;R50

[ 安全声明 (欧洲) ]:
S9-S26-S36/37/39-S45-S61-S7/8

[ 危险品运输编码 ]:
UN 1752 6.1/PG 1

[ WGK德国 ]:
3

[ RTECS号 ]:
AO6475000

[ 包装等级 ]:
I

[ 危险类别 ]:
6.1

[ 海关编码 ]:
2915900090

氯乙酰氯合成路线

氯乙酰氯上下游产品

氯乙酰氯上游产品

氯乙酰氯下游产品

氯乙酰氯制备

点击显示

氯乙酰氯海关

[ 海关编码 ]: 2915900090

[ 中文概述 ]:
2915900090. 其他饱和无环一元羧酸及其酸酐（酰卤、过氧）化物、过氧酸及其卤化、硝化、磺化、亚硝化衍生物. 增值税率:17.0%. 退税率:9.0%. 监管条件:AB(入境货物通关单,出境货物通关单). 最惠国关税:5.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验

[ Summary ]:
2915900090 other saturated acyclic monocarboxylic acids and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:5.5% General tariff:30.0%

氯乙酰氯文献

Comparative evaluation of Bis(thiosemicarbazone)- Biotin and Met-ac-TE3A for tumor imaging.

Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 153 , 566-71, (2015)

2,2',2″-(11-(2-((4-mercapto-1-methoxy-1-oxobutan-2-yl)amino)-2-oxoethyl)-1,4,8,11-tetraaza cyclotetradecane-1,4,8-triyl)triacetic acid, Met-ac-TE3A and (E)-N-methyl-2-((E)-3-(2-(2-(5-((3aS,4S,6aR)-2-o...

New hydrazines with sulphonamidic structure: synthesis,characterization and biological activity.

Rev. Med. Chir. Soc. Med. Nat. Iasi. 117(1) , 238-43, (2013)

Infections caused by bacterial species are common in immunocompromised patients and carry significant treatment costs and mortality. The emerging resistance of microorganisms to some synthetic antimic...

Cysteine cyclic pyrrole-imidazole polyamide for sequence-specific recognition in the DNA minor groove.

J. Am. Chem. Soc. 133(46) , 18924-30, (2011)

Pyrrole-imidazole (PI) polyamides are small DNA-binding molecules that can recognize predetermined DNA sequences with high affinity and specificity. Hairpin PI polyamides have been studied intensively...

更多文献

氯乙酰氯

氯乙酰氯用途

氯乙酰氯名称

氯乙酰氯物理化学性质

氯乙酰氯MSDS

详细MSDS(安全技术说明书)

氯乙酰氯毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

氯乙酰氯安全信息

氯乙酰氯合成路线

详细合成路线

氯乙酰氯上下游产品

氯乙酰氯上游产品

氯乙酰氯下游产品

氯乙酰氯制备

氯乙酰氯海关

氯乙酰氯文献

相关化工产品/化学物质：

推荐生产厂家/供应商：

相关化合物