乌沙甙元

乌沙甙元用途

Uzarigenin (NSC 119993; NSC 277290; Odorigeni) 是一种可以从 Pergularia tomentosa 中分离得到的卡氏内酯,具有抗增殖活性。Uzarigenin 抗 PC3细胞,HeLa细胞,Calu-1细胞,MCF-7细胞和 U251MG细胞增殖,IC50 值分别为0.3 μM、3.0 μM、8.0 μM、6.0 μM和 6.0 μM。

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乌沙甙元名称

[ CAS 号 ]:
466-09-1

[ 中文名 ]:
乌沙甙元

[ 英文名 ]:
Odorigenin

[英文别名 ]:

Odorigenin
5α-Card-20(22)-enolide, 3β,14-dihydroxy-
3b,14-Dihydroxy-5a-card-20(22)-enolide
UZARIGENIN
ODORIGENIN B
Card-20(22)-enolide, 3,14-dihydroxy-, (3β,5α)-
(3β,5α)-3,14-Dihydroxycard-20(22)-enolide
uzarigenine

乌沙甙元生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Hosseini SH, et al. Antiproliferative Cardenolides from the Aerial Parts of Pergularia tomentosa. J Nat Prod. 2019 Jan 25;82(1):74-79.

乌沙甙元物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
549.3±50.0 °C at 760 mmHg

[ 熔点 ]:
240-256°

[ 分子式 ]:
C₂₃H₃₄O₄

[ 分子量 ]:
374.514

[ 闪点 ]:
188.2±23.6 °C

[ 精确质量 ]:
374.245697

[ PSA ]:
66.76000

[ LogP ]:
2.79

[ 外观性状 ]:
粉末

[ 蒸汽压 ]:
0.0±3.4 mmHg at 25°C

[ 折射率 ]:
1.591

[ 储存条件 ]:
2-8℃，干燥，密闭

乌沙甙元毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YV1950000

CHEMICAL NAME :: Uzarigenin

CAS REGISTRY NUMBER :: 466-09-1

BEILSTEIN REFERENCE NO. :: 0095446

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C23-H34-O4

MOLECULAR WEIGHT :: 374.57

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 1379 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 13,1029,1970 *** REVIEWS *** TOXICOLOGY REVIEW 85ELDJ "Die Herzwirksamen Glykoside," Baumgarten, G., and W. Forster, Leipzig, Ger. Dem. Rep., VEB Georg Thieme, 1963 Volume(issue)/page/year: -,194,1963