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邻苯二甲酰甘氨酸

邻苯二甲酰甘氨酸名称

[ CAS 号 ]:
4702-13-0

[ 中文名 ]:
邻苯二甲酰甘氨酸

[ 英文名 ]:
N-Phthaloylglycine

[中文别名 ]:

[英文别名 ]:

PHTHALYL GLYCINE
Phthalimidoacetic acid
N-Phthaloylglycine
n-phthalylglycin
2H-Isoindole-2-acetic acid, 1,3-dihydro-1,3-dioxo-
N-phtaloyl glycine
1,3-Dioxo-2-isoindolineacetic acid
2-phthalimidoacetic acid
PHT-GLY-OH
PHTHALOYLGLYCINE

邻苯二甲酰甘氨酸物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 沸点 ]:
412.6±28.0 °C at 760 mmHg

[ 熔点 ]:
193-196 °C(lit.)

[ 分子式 ]:
C₁₀H₇NO₄

[ 分子量 ]:
205.167

[ 闪点 ]:
203.3±24.0 °C

[ 精确质量 ]:
205.037506

[ PSA ]:
74.68000

[ LogP ]:
1.19

[ 外观性状 ]:
略奶油色色的,近乎于无气味的粉末

[ 蒸汽压 ]:
0.0±1.0 mmHg at 25°C

[ 折射率 ]:
1.640

[ 储存条件 ]:
0-6°C

[ 水溶解性 ]:
insoluble

邻苯二甲酰甘氨酸MSDS

邻苯二甲酰甘氨酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NR3439000

CHEMICAL NAME :: 2-Isoindolineacetic acid, 1,3-dioxo-

CAS REGISTRY NUMBER :: 4702-13-0

BEILSTEIN REFERENCE NO. :: 0184174

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C10-H7-N-O4

MOLECULAR WEIGHT :: 205.18

WISWESSER LINE NOTATION :: T56 BVNVJ C1VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 200 mg/kg

SEX/DURATION :: female 9 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - other developmental abnormalities

REFERENCE :: PHARAT Pharmazie. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1946- Volume(issue)/page/year: 28,680,1973

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邻苯二甲酰甘氨酸安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xn:Harmful;

[ 风险声明 (欧洲) ]:
R22;R36/37/38

[ 安全声明 (欧洲) ]:
S22-S24/25-S36/37/39-S26

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
NR3439000

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邻苯二甲酰甘氨酸文献

N-phthaloyl-glycine-hydroxamic acid as serum iron chelator in rats.

Acta. Pharm. 58(2) , 231-6, (2008)

The aim of this study was to investigate the activity of N-phthaloyl-glycine-hydroxamic acid (Phth-Gly-HA) as a new iron chelator in vivo to be used in iron overload diseases. After intraperitoneal ap...

Comparative pharmacokinetic and pharmacodynamic analysis of phthaloyl glycine derivatives with potential antiepileptic activity.

Pharm. Res. 11(10) , 1429-34, (1994)

Glycine, in addition to GABA, is one of the most important neurotransmitter amino acids. The described structure pharmacokinetic pharmacodynamic relationships (SPPR) study explored the possibility of ...

Synthesis, crystal structure, DNA binding and in vitro biological studies of Ni(II), Cu(II) and Zn(II) complexes of N-phthaloylglycine.

J. Photochem. Photobiol. B, Biol. 117 , 228-39, (2012)

Ni(II), Cu(II) and Zn(II) metal complexes of N-phthaloylglycine were synthesized, characterized, reported for single crystal X-ray diffraction analysis for Ni(II) complex, and investigated for their b...

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