花姜酮

花姜酮用途

Zerumbone 是从Zingiber zerumbet Smith 的根茎中分离出来的单环倍半萜烯化合物。Zerumbone 有效抑制Epstein-Barr 病毒的激活,IC50 为 0.14 mM。Zerumbone 具有抗癌,抗氧化,抗炎,抗增殖的作用。

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花姜酮名称

[ CAS 号 ]:
471-05-6

[ 中文名 ]:
花薑酮

[ 英文名 ]:
zerumbone

[中文别名 ]:

花姜酮

[英文别名 ]:

zerumbone

花姜酮生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 抗感染 >> HSV

研究领域 >> 感染

[参考文献]

[1]. Murakami A, et al. Identification of zerumbone in Zingiber zerumbet Smith as a potent inhibitor of 12-O-tetradecanoylphorbol-13-acetate-induced Epstein-Barr virus activation. Biosci Biotechnol Biochem. 1999 Oct;63(10):1811-2.

[2]. Kalantari K, et al. A Review of the Biomedical Applications of Zerumbone and the Techniques for Its Extractionfrom Ginger Rhizomes. Molecules. 2017 Sep 30;22(10).

花姜酮物理化学性质

[ 密度 ]:
0.9±0.1 g/cm3

[ 沸点 ]:
321.6±42.0 °C at 760 mmHg

[ 熔点 ]:
67-69℃

[ 分子式 ]:
C₁₅H₂₂O

[ 分子量 ]:
218.335

[ 闪点 ]:
133.9±22.8 °C

[ 精确质量 ]:
218.167068

[ PSA ]:
17.07000

[ LogP ]:
5.34

[ 蒸汽压 ]:
0.0±0.7 mmHg at 25°C

[ 折射率 ]:
1.468

[ 储存条件 ]:
2-8℃

花姜酮安全信息

[ 符号 ]:

GHS07, GHS09

[ 信号词 ]:
Warning

[ 危害声明 ]:
H317-H400

[ 警示性声明 ]:
P273-P280

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
43-50

[ 安全声明 (欧洲) ]:
36/37-60-61

[ 危险品运输编码 ]:
UN 3077 9 / PGIII

花姜酮文献

Zingiber zerumbet CYP71BA1 catalyzes the conversion of α-humulene to 8-hydroxy-α-humulene in zerumbone biosynthesis.

Cell. Mol. Life Sci. 68(6) , 1033-40, (2011)

Plant cytochrome P450s are involved in the biosynthesis of various classes of secondary metabolites. To elucidate the biosynthesis of zerumbone, a sesquiterpenoid with multiple potential anticancer pr...

Altered cross-linking of HSP27 by zerumbone as a novel strategy for overcoming HSP27-mediated radioresistance.

Int. J. Radiat. Oncol. Biol. Phys. 79(4) , 1196-205, (2011)

HSP27 or HSP25 negatively regulates apoptosis pathways after radiation or chemotherapeutic agents. Abrogation of HSP27 function may be a candidate target for overcoming radio- and chemoresistance.Zeru...

Effects of selected food phytochemicals in reducing the toxic actions of TCDD and p,p'-DDT in U937 macrophages.

Arch. Toxicol. 84(12) , 957-66, (2010)

To assess the effectiveness of selected food phytochemicals in reducing the toxic effects of the environmental toxicants, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and p,p'-DDT (DDT), we tested the p...

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花姜酮