(E)-10-Hydroxynortriptyline

(E)-10-Hydroxynortriptyline用途

(E)-10-Hydroxynortriptyline (E-10-OH-NT) 是 Nortriptyline (HY-B1417) 的代谢物。Nortriptyline 是三环类抗抑郁药,是 Amitriptyline 的主要活性代谢物,用于缓解抑郁症状。
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(E)-10-Hydroxynortriptyline名称

[ CAS 号 ]:
47132-16-1

[ 英文名 ]:
(E)-10-Hydroxynortriptyline

[英文别名 ]:

(E)-10-Hydroxynortriptyline生物活性

[ 描述 ]:

(E)-10-Hydroxynortriptyline (E-10-OH-NT) 是 Nortriptyline (HY-B1417) 的代谢物。Nortriptyline 是三环类抗抑郁药,是 Amitriptyline 的主要活性代谢物,用于缓解抑郁症状。

[ 相关类别 ]:

研究领域 >> 神经疾病

[参考文献]

[1]. Shimoda K, et al. The impact of CYP2C19 and CYP2D6 genotypes on metabolism of amitriptyline in Japanese psychiatric patients. J Clin Psychopharmacol. 2002 Aug;22(4):371-8.

[2]. Shimoda K, et al. Dean L. Amitriptyline Therapy and CYP2D6 and CYP2C19 Genotype. Biotechnology Information (US); 2012-2017 Mar 23.

(E)-10-Hydroxynortriptyline物理化学性质

[ 密度 ]:
1.164g/cm3

[ 沸点 ]:
462.3ºC at 760mmHg

[ 分子式 ]:
C19H21NO

[ 分子量 ]:
279.37600

[ 闪点 ]:
142.1ºC

[ 精确质量 ]:
279.16200

[ PSA ]:
32.26000

[ LogP ]:
3.70820

(E)-10-Hydroxynortriptyline合成路线

详细合成路线

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