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(E)-10-Hydroxynortriptyline

更新时间:2024-01-18 22:37:48

(E)-10-Hydroxynortriptyline结构式
(E)-10-Hydroxynortriptyline结构式
品牌特惠专场
常用名 (E)-10-Hydroxynortriptyline 英文名 (E)-10-Hydroxynortriptyline
CAS号 47132-16-1 分子量 279.37600
密度 1.164g/cm3 沸点 462.3ºC at 760mmHg
分子式 C19H21NO 熔点 N/A
MSDS N/A 闪点 142.1ºC

 (E)-10-Hydroxynortriptyline用途


(E)-10-Hydroxynortriptyline (E-10-OH-NT) 是 Nortriptyline (HY-B1417) 的代谢物。Nortriptyline 是三环类抗抑郁药,是 Amitriptyline 的主要活性代谢物,用于缓解抑郁症状。

 (E)-10-Hydroxynortriptyline名称

英文名 ()-trans-10-hydroxynortriptyline
英文别名 更多

 (E)-10-Hydroxynortriptyline生物活性

描述 (E)-10-Hydroxynortriptyline (E-10-OH-NT) 是 Nortriptyline (HY-B1417) 的代谢物。Nortriptyline 是三环类抗抑郁药,是 Amitriptyline 的主要活性代谢物,用于缓解抑郁症状。
相关类别
参考文献

[1]. Shimoda K, et al. The impact of CYP2C19 and CYP2D6 genotypes on metabolism of amitriptyline in Japanese psychiatric patients. J Clin Psychopharmacol. 2002 Aug;22(4):371-8.

[2]. Shimoda K, et al. Dean L. Amitriptyline Therapy and CYP2D6 and CYP2C19 Genotype. Biotechnology Information (US); 2012-2017 Mar 23.

 (E)-10-Hydroxynortriptyline物理化学性质

密度 1.164g/cm3
沸点 462.3ºC at 760mmHg
分子式 C19H21NO
分子量 279.37600
闪点 142.1ºC
精确质量 279.16200
PSA 32.26000
LogP 3.70820

 (E)-10-Hydroxynortriptyline合成线路

~91%

(E)-10-Hydroxynortriptyline结构式

(E)-10-Hydroxyn...

47132-16-1

文献:Jean-Claude; Just Synthetic Communications, 1994 , vol. 24, # 11 p. 1565 - 1573

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(E)-10-Hydroxynortriptyline结构式

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47132-16-1

文献:Jean-Claude; Just Synthetic Communications, 1994 , vol. 24, # 11 p. 1565 - 1573

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(E)-10-Hydroxynortriptyline结构式

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47132-16-1

文献:Lassen; Perregaard 1983 , vol. 37, # 4 B p. 335 - 340

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(E)-10-Hydroxynortriptyline结构式

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47132-16-1

文献:Lassen; Perregaard 1983 , vol. 37, # 4 B p. 335 - 340

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(E)-10-Hydroxynortriptyline结构式

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文献:Lassen; Perregaard 1983 , vol. 37, # 4 B p. 335 - 340

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(E)-10-Hydroxynortriptyline结构式

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文献:Lassen; Perregaard 1983 , vol. 37, # 4 B p. 335 - 340

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(E)-10-Hydroxynortriptyline结构式

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文献:Lassen; Perregaard 1983 , vol. 37, # 4 B p. 335 - 340

~%

(E)-10-Hydroxynortriptyline结构式

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47132-16-1

文献:Lassen; Perregaard 1983 , vol. 37, # 4 B p. 335 - 340

~%

(E)-10-Hydroxynortriptyline结构式

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47132-16-1

文献:Masubuchi, Yasuhiro; Iwasa, Takashi; Fujita, Shoichi; Suzuki, Tokuji; Horie, Toshiharu; Narimatsu, Shizuo Journal of Pharmacy and Pharmacology, 1996 , vol. 48, # 9 p. 925 - 929

 (E)-10-Hydroxynortriptyline英文别名

E-10-hydroxynortriptyline
trans-10-Hydroxy Nortriptyline Maleate
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