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秋水仙碱苷

秋水仙碱苷用途

Colchicoside 是一种具有抗利什曼原虫和抗利什曼原虫活性的生物活性生物碱 (tropolone alkaloid) [1]。

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秋水仙碱苷名称

[ CAS 号 ]:
477-29-2

[ 中文名 ]:
秋水仙碱苷

[ 英文名 ]:
Colchicoside

[英文别名 ]:

colchicoside

秋水仙碱苷生物活性

[ 描述 ]:

Colchicoside 是一种具有抗利什曼原虫和抗利什曼原虫活性的生物活性生物碱 (tropolone alkaloid) [1]。

[ 相关类别 ]:

研究领域 >> 感染

[参考文献]

[1]. Mohammad Azadbakht, et al. Tropolone alkaloids from Colchicum kurdicum (Bornm.) Stef. (Colchicaceae) as the potent novel antileishmanial compounds; purification, structure elucidation, antileishmanial activities and molecular docking studies. Exp Parasitol. 2020 Jun;213:107902.

秋水仙碱苷物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
929.0±65.0 °C at 760 mmHg

[ 熔点 ]:
194-197ºC

[ 分子式 ]:
C₂₇H₃₃NO₁₁

[ 分子量 ]:
547.55

[ 闪点 ]:
515.6±34.3 °C

[ 精确质量 ]:
547.205383

[ PSA ]:
173.24000

[ LogP ]:
-1.76

[ 蒸汽压 ]:
0.0±0.3 mmHg at 25°C

[ 折射率 ]:
1.636

[ 储存条件 ]:
库房低温,通风,干燥,与食品原料分开存放

秋水仙碱苷毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GH0982000

CHEMICAL NAME :: Colchicoside

CAS REGISTRY NUMBER :: 477-29-2

BEILSTEIN REFERENCE NO. :: 0072204

LAST UPDATED :: 199612

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C27-H33-N-O11

MOLECULAR WEIGHT :: 547.61

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intracerebral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 75 ug/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 109,386,1957

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 75 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 15,533,1960

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 84 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 94,453,1953

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 280 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 109,386,1957

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 320 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 94,453,1953

秋水仙碱苷

秋水仙碱苷用途

秋水仙碱苷名称

秋水仙碱苷生物活性

秋水仙碱苷物理化学性质

秋水仙碱苷毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

秋水仙碱苷安全信息

秋水仙碱苷上下游产品

秋水仙碱苷上游产品

秋水仙碱苷下游产品

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