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(±)-AC 7954 hydrochloride

(±)-AC 7954 hydrochloride用途

AC-7954 是一种选择性非肽尾加压素受体激动剂 (EC50: 对人 UII 受体为 300 nM)。

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(±)-AC 7954 hydrochloride名称

[ CAS 号 ]:
477313-09-0

[ 中文名 ]:
(±)-AC 7954 hydrochloride

[ 英文名 ]:
AC-7954

[英文别名 ]:

ac-7954

(±)-AC 7954 hydrochloride生物活性

[ 描述 ]:

AC-7954 是一种选择性非肽尾加压素受体激动剂 (EC50: 对人 UII 受体为 300 nM)。

[ 相关类别 ]:

研究领域 >> 心血管疾病

信号通路 >> G 蛋白偶联受体/G 蛋白 >> Urotensin Receptor

[参考文献]

[1]. Croston GE, et al. Discovery of the first nonpeptide agonist of the GPR14/urotensin-II receptor: 3-(4-chlorophenyl)-3-(2- (dimethylamino)ethyl)isochroman-1-one (AC-7954). J Med Chem. 2002 Nov 7;45(23):4950-3.

(±)-AC 7954 hydrochloride物理化学性质

[ 沸点 ]:
462.8ºC at 760 mmHg

[ 分子式 ]:
C₁₉H₂₁Cl₂NO₂

[ 分子量 ]:
366.28200

[ 闪点 ]:
233.7ºC

[ 精确质量 ]:
365.09500

[ PSA ]:
29.54000

[ LogP ]:
4.70210

[ 外观性状 ]:
白色固体

(±)-AC 7954 hydrochlorideMSDS

详细MSDS(安全技术说明书)

(±)-AC 7954 hydrochloride安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

(±)-AC 7954 hydrochloride文献

Unraveling the active conformation of urotensin II.

J. Med. Chem. 47 , 1652-61, (2004)

Urotensin II (U-II) is a disulfide-bridged undecapeptide recently identified as the ligand of an orphan G-protein-coupled receptor. Human U-II (H-Glu-Thr-Pro-Asp-cyclo[Cys-Phe-Trp-Lys-Tyr-Cys]-Val-OH)...

Discovery of the first nonpeptide agonist of the GPR14/urotensin-II receptor: 3-(4-chlorophenyl)-3-(2- (dimethylamino)ethyl)isochroman-1-one (AC-7954).

J. Med. Chem. 45 , 4950-4953, (2002)

A functional cell-based screen identified 3-(4-chlorophenyl)-3-(2-(dimethylamino)ethyl)isochroman-1-one hydrochloride (AC-7954, 1) as a nonpeptidic agonist of the urotensin-II receptor. Racemic 1 had ...

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