全缘千里光碱

全缘千里光碱用途

(-)-整合子嘧啶,一种吡咯里西啶生物碱,具有抗溃疡活性。(-)-整合子亚胺也是果蝇中的一种致突变和弱致碎屑剂[1][2]。

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全缘千里光碱名称

[ CAS 号 ]:
480-79-5

[ 中文名 ]:
全緣千里光鹼

[ 英文名 ]:
Integerrimine

[英文别名 ]:

Intergerrimine
senecionyne
Squalidine
INTEGERRIMINE
seneciionine
12-hydroxy-senecionane-11,16-dione

全缘千里光碱生物活性

[ 描述 ]:

(-)-整合子嘧啶,一种吡咯里西啶生物碱,具有抗溃疡活性。(-)-整合子亚胺也是果蝇中的一种致突变和弱致碎屑剂[1][2]。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 炎症/免疫

[体外研究]

(-)-整合子亚胺(0.00625-0.05 mM)在果蝇体细胞中也必须具有诱变活性。(-)-整合素亚胺通常需要细胞色素P450依赖性代谢激活来显示遗传毒性活性[1]。

[参考文献]

[1]. V R Campesato, et al. Recombinagenic activity of integerrimine, a pyrrolizidine alkaloid from Senecio brasiliensis, in somatic cells of Drosophila melanogaster. Environ Mol Mutagen. 1997;29(1):91-7.

[2]. Walber Toma, et al. Modulation of gastrin and epidermal growth factor by pyrrolizidine alkaloids obtained from Senecio brasiliensis in acute and chronic induced gastric ulcers. Can J Physiol Pharmacol. 2004 May;82(5):319-25.

全缘千里光碱物理化学性质

[ 密度 ]:
1.25g/cm3

[ 沸点 ]:
563.7ºC at 760 mmHg

[ 熔点 ]:
172 °C

[ 分子式 ]:
C₁₈H₂₅NO₅

[ 分子量 ]:
335.39500

[ 闪点 ]:
294.7ºC

[ 精确质量 ]:
335.17300

[ PSA ]:
76.07000

[ LogP ]:
1.13070

[ 蒸汽压 ]:
4.68E-15mmHg at 25°C

[ 折射率 ]:
1.57

[ 储存条件 ]:
-20°C，干燥，密封

全缘千里光碱毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NM9080000

CHEMICAL NAME :: Integerrimine

CAS REGISTRY NUMBER :: 480-79-5

LAST UPDATED :: 199603

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C18-H25-N-O5

MOLECULAR WEIGHT :: 335.44

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 75 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 78 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 300 mg/kg/20D-I

TOXIC EFFECTS :: Related to Chronic Data - death

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 18750 ug/kg

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 241,297,1990

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全缘千里光碱安全信息

[ 危害码 (欧洲) ]:
Xi

[ 危险品运输编码 ]:
UN 1544

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)