白当归素

白当归素用途

Byakangelicin 是一种在当归 (Angelica gigas) 根中发现的活性化合物,可以作为调节剂,改善各种活性化合物 (Umb,Cur 和 Dox) 的脑积累,增强治疗效果。Byakangelicin 增加所有 PXR 靶基因 (如MDR1) 的表达,并诱导广泛的药物-药物相互作用。Byakangelicin 可以抑制性激素的作用,它可能会增加内源激素的分解代谢。

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白当归素名称

[ CAS 号 ]:
482-25-7

[ 中文名 ]:
白当归素

[ 英文名 ]:
Byakangelicin

[英文别名 ]:

白当归素生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 代谢疾病

[ 靶点 ]

PXR[2]

[参考文献]

[1]. Kang YY, et al. Byakangelicin as a modulator for improved distribution and bioactivity of natural compounds and synthetic drugs in the brain. Phytomedicine. 2019 May 17;62:152963.

[2]. Yang J, et al. Byakangelicin induces cytochrome P450 3A4 expression via transactivation of pregnane X receptors in human hepatocytes. Br J Pharmacol. 2011 Jan;162(2):441-51.

白当归素物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
571.5±50.0 °C at 760 mmHg

[ 熔点 ]:
123-124℃

[ 分子式 ]:
C₁₇H₁₈O₇

[ 分子量 ]:
334.321

[ 闪点 ]:
299.4±30.1 °C

[ 精确质量 ]:
334.105255

[ PSA ]:
102.27000

[ LogP ]:
1.62

[ 外观性状 ]:
粉末

[ 蒸汽压 ]:
0.0±1.7 mmHg at 25°C

[ 折射率 ]:
1.613

[ 储存条件 ]:
?20°C

白当归素安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
22-36/37/38

[ 安全声明 (欧洲) ]:
26

[ 危险品运输编码 ]:
NONH for all modes of transport

白当归素文献

Simultaneous determination of byak-angelicin and oxypeucedanin hydrate in rat plasma by column-switching high-performance liquid chromatography with ultraviolet detection.

J. Chromatogr. B. Biomed. Sci. Appl. 753(2) , 309-14, (2001)

A simple and sensitive column-switching HPLC method was developed for the simultaneous determination of two furocoumarin compounds, byak-angelicin and oxypeucedanin hydrate, which are the main compone...

[Studies on quality standards of radix Angelicae dahuricae].

Zhongguo Zhong Yao Za Zhi 29(7) , 654-7, (2004)

To work out a qualitay standard of Radix Angelicae dahuricae.TLC and HPLC were adopted.Four coumerin compounds were identified by TLC, and the contents of two compounds were determined by HPLC.Imperat...

Furocoumarins from Angelica dahurica with hepatoprotective activity on tacrine-induced cytotoxicity in Hep G2 cells.

Planta Med. 68(5) , 463-4, (2002)

Fractionation of the MeOH extract of Angelica dahurica Benth et Hook resulted in the isolation of six furocoumarins, imperatorin (1), isoimperatorin (2), (+/-)-byakangelicol (3), (+)-oxypeucedanin (4)...

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