Fervenulin
Fervenulin用途
Fervenulin 从杀线虫放线菌链霉菌属菌 CMU-MH021 中分离的,具有杀线虫 (nematicidal) 活性,抑制线虫的卵孵化和 J2 的校正死亡率,MIC 分别为 30 μg/mL 和 120 μg/mL。
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Fervenulin名称
[ CAS 号 ]:
483-57-8
[ 英文名 ]:
fervenulin
[英文别名 ]:
- Fervenuline
- Kc 1017
- Compound 7215
- U-7118
- Planomycin
- Pulanomycin
- Phervenulin
Fervenulin生物活性
[ 描述 ]:
Fervenulin 从杀线虫放线菌链霉菌属菌 CMU-MH021 中分离的,具有杀线虫 (nematicidal) 活性,抑制线虫的卵孵化和 J2 的校正死亡率,MIC 分别为 30 μg/mL 和 120 μg/mL。
[ 相关类别 ]:
[ 靶点 ]
Nematicidal[1]
[体外研究]
阿魏蛋白具有广泛的生物学活性,如体外抗菌、抗真菌、抗寄生虫和抗肿瘤等。在250μg/mL浓度下孵育96h后,阿魏素对隐翅虫二期线虫幼体的杀灭率可达100%。
[参考文献]
Fervenulin物理化学性质
[ 密度 ]:
1.474g/cm3
[ 沸点 ]:
417.2ºC at 760 mmHg
[ 分子式 ]:
C7H7N5O2
[ 分子量 ]:
193.16300
[ 闪点 ]:
206.1ºC
[ 精确质量 ]:
193.06000
[ PSA ]:
82.67000
[ 蒸汽压 ]:
3.61E-07mmHg at 25°C
[ 折射率 ]:
1.601
Fervenulin毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- UW7900000
- CHEMICAL NAME :
- Pyrimido(5,4-e)-as-triazine-5,7(6H,8H)-dione, 6,8-dimethyl-
- CAS REGISTRY NUMBER :
- 483-57-8
- LAST UPDATED :
- 199603
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C7-H7-N5-O2
- MOLECULAR WEIGHT :
- 193.19
- WISWESSER LINE NOTATION :
- T66 BVNVN GNN JNJ C1 E1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 65 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ABANAE Antibiotics Annual. (New York, NY) 1953-60. For publisher information, see AMACCQ. Volume(issue)/page/year: 7,220,1959/1960
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 15 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 5,199,1981
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 20 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 85FZAT "Index of Antibiotics from Actinomycetes," Umezawa, H. et al., eds., Tokyo, Univ. of Tokyo Press, 1967 Volume(issue)/page/year: -,518,1967
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - hamster
- DOSE/DURATION :
- 11200 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ABANAE Antibiotics Annual. (New York, NY) 1953-60. For publisher information, see AMACCQ. Volume(issue)/page/year: 7,220,1959/1960
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Fervenulin合成路线
Fervenulin上下游产品
Fervenulin上游产品
Fervenulin下游产品
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