3-吲哚甲醛

3-吲哚甲醛用途

Indole-3-carboxaldehyde (3-Formylindole) 是一种卷心菜提取物,是由黄化豌豆幼苗的粗酶制剂氧化降解IAA 的产物。Indole-3-carboxaldehyde (3-Formylindole) 可用于制备吲哚类植物抗毒素环芸香素类似物。

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3-吲哚甲醛名称

[ CAS 号 ]:
487-89-8

[ 中文名 ]:
3-吲哚甲醛

[ 英文名 ]:
Indole-3-carboxaldehyde

[中文别名 ]:

[英文别名 ]:

3-Indolecarboxaldehyde
INDOLE-3-ALDEHYDE
1H-Indole-3-carboxaldehyde
indole-3-carbaldehyde
1H-Indole-3-carbaldehyde
I3CA
indol-3-carboxaldehyde
INDOL-3-ALDEHYDE
3-Formylindol
3-Indolealdehyde

3-吲哚甲醛生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Robert E. Stutz, et al. Enzymatic Formation of Indole-3-Carboxaldehyde from Indole-3-Acetic Acid. Plant Physiol. 1958 May; 33(3): 207–212.

3-吲哚甲醛物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
339.1±15.0 °C at 760 mmHg

[ 熔点 ]:
193-198 °C(lit.)

[ 分子式 ]:
C₉H₇NO

[ 分子量 ]:
145.158

[ 闪点 ]:
166.8±27.8 °C

[ 精确质量 ]:
145.052765

[ PSA ]:
32.86000

[ LogP ]:
1.68

[ 外观性状 ]:
白色至灰白色晶体

[ 蒸汽压 ]:
0.0±0.7 mmHg at 25°C

[ 折射率 ]:
1.729

[ 储存条件 ]:
Keep Cold

3-吲哚甲醛MSDS

3-吲哚甲醛毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NL5993600

CHEMICAL NAME :: Indole-3-carboxaldehyde

CAS REGISTRY NUMBER :: 487-89-8

BEILSTEIN REFERENCE NO. :: 0114117

LAST UPDATED :: 199701

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C9-H7-N-O

MOLECULAR WEIGHT :: 145.17

WISWESSER LINE NOTATION :: T56 BMJ DVH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 600 mg/kg

TOXIC EFFECTS :: Autonomic Nervous System - smooth muscle relaxant (mechanism undefined, spasmolytic) Behavioral - anticonvulsant Behavioral - changes in motor activity (specific assay)

REFERENCE :: PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 6,33,1972

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3-吲哚甲醛安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
NL5993600

[ 海关编码 ]:
2942000000

3-吲哚甲醛合成路线

3-吲哚甲醛上下游产品

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3-吲哚甲醛下游产品

3-吲哚甲醛海关

[ 海关编码 ]: 2942000000

3-吲哚甲醛文献

A chemical screening approach reveals that indole fluorescence is quenched by pre-fibrillar but not fibrillar amyloid-beta.

Bioorg. Med. Chem. Lett. 19 , 4952-7, (2009)

Aggregated amyloid-beta (Abeta) peptide is implicated in the pathology of Alzheimer's disease. In vitro and in vivo, these aggregates are found in a variety of morphologies, including globular oligome...

Antioxidative properties of ascorbigen in using multiple antioxidant assays.

Biosci. Biotechnol. Biochem. 78(10) , 1723-30, (2014)

The antioxidative properties of ascorbigen, one of the major indole-derived compounds of Brassica vegetables, were systematically evaluated using multiple assay systems with comparison to the well-kno...

Rational design of novel CYP2A6 inhibitors.

Bioorg. Med. Chem. 22(23) , 6655-64, (2015)

Inhibition of CYP2A6-mediated nicotine metabolism can reduce cigarette smoking. We sought potent and selective CYP2A6 inhibitors to be used as leads for drugs useful in smoking reduction therapy, by e...

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