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二氢吲哚

二氢吲哚用途

用于制药

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二氢吲哚名称

[ CAS 号 ]:
496-15-1

[ 中文名 ]:
吲哚啉

[ 英文名 ]:
Indoline

[中文别名 ]:

[英文别名 ]:

2,3-dihydro-1H-1-indole
Indoline
IDN
trans-dihydroindole
2,3-dihydro-1H-indole
EINECS 207-816-8
MFCD00005705
2,3-DIHYDROINDOLE
1H-Indole, 2,3-dihydro-
1-Azaindan

二氢吲哚物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
227.2±10.0 °C at 760 mmHg

[ 熔点 ]:
-21 °C

[ 分子式 ]:
C₈H₉N

[ 分子量 ]:
119.164

[ 闪点 ]:
92.8±0.0 °C

[ 精确质量 ]:
119.073502

[ PSA ]:
12.03000

[ LogP ]:
1.63

[ 外观性状 ]:
透明至黄色液体

[ 蒸汽压 ]:
0.1±0.4 mmHg at 25°C

[ 折射率 ]:
1.562

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
5 g/L (20 ºC)

二氢吲哚MSDS

二氢吲哚毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NL6906300

CHEMICAL NAME :: 1H-Indole, 2,3-dihydro-

CAS REGISTRY NUMBER :: 496-15-1

BEILSTEIN REFERENCE NO. :: 0111915

LAST UPDATED :: 199710

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C8-H9-N

MOLECULAR WEIGHT :: 119.18

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >238 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 94,1620,1974

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二氢吲哚安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;half-mask respirator (US);multi-purpose combination respirator cartridge (US)

[ 危害码 (欧洲) ]:
Xi:Irritant

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S23-S24/25-S37/39-S26

[ WGK德国 ]:
3

[ RTECS号 ]:
NL6906300

[ 海关编码 ]:
2933990090

二氢吲哚合成路线

二氢吲哚上下游产品

二氢吲哚上游产品

二氢吲哚下游产品

二氢吲哚海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

二氢吲哚文献

Palladium-catalyzed insertion of N-tosylhydrazones for the synthesis of isoindolines.

Chem. Commun. (Camb.) 49(31) , 3254-6, (2013)

Isoindolines are synthesized by palladium-catalyzed coupling reaction of N-(2-iodobenzyl) anilines with α,β-unsaturated N-tosylhydrazones. The reaction has several potential advantages: (1) toleration...

FeCl3-mediated Friedel-Crafts hydroarylation with electrophilic N-acetyl indoles for the synthesis of benzofuroindolines.

Angew. Chem. Int. Ed. Engl. 51(50) , 12546-50, (2012)

IRONic electrophilic indoles! The C3-regioselective hydroarylation of N-acetyl indoles with aromatic nucleophiles mediated by FeCl(3) features a rare example of the electrophilic reactivity of the ind...

Identification and Testing of Novel CARP-1 Functional Mimetic Compounds as Inhibitors of Non-Small Cell Lung and Triple Negative Breast Cancers.

J. Biomed. Nanotechnol. 11 , 1608-27, (2015)

The triple negative breast cancer (TNBCs) and non-small cell lung cancers (NSCLCs) often acquire mutations that contribute to failure of drugs in clinic and poor prognosis, thus presenting an urgent n...

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