二氢吲哚
二氢吲哚结构式
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常用名 | 二氢吲哚 | 英文名 | Indoline |
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| CAS号 | 496-15-1 | 分子量 | 119.164 | |
| 密度 | 1.0±0.1 g/cm3 | 沸点 | 227.2±10.0 °C at 760 mmHg | |
| 分子式 | C8H9N | 熔点 | -21 °C | |
| MSDS | 中文版 美版 | 闪点 | 92.8±0.0 °C |
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Palladium-catalyzed insertion of N-tosylhydrazones for the synthesis of isoindolines.
Chem. Commun. (Camb.) 49(31) , 3254-6, (2013) Isoindolines are synthesized by palladium-catalyzed coupling reaction of N-(2-iodobenzyl) anilines with α,β-unsaturated N-tosylhydrazones. The reaction has several potential advantages: (1) toleration of a wide range of functional groups, (2) easy to handle a... |
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FeCl3-mediated Friedel-Crafts hydroarylation with electrophilic N-acetyl indoles for the synthesis of benzofuroindolines.
Angew. Chem. Int. Ed. Engl. 51(50) , 12546-50, (2012) IRONic electrophilic indoles! The C3-regioselective hydroarylation of N-acetyl indoles with aromatic nucleophiles mediated by FeCl(3) features a rare example of the electrophilic reactivity of the indole core in a Friedel-Crafts reaction. This indole umpolung... |
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Identification and Testing of Novel CARP-1 Functional Mimetic Compounds as Inhibitors of Non-Small Cell Lung and Triple Negative Breast Cancers.
J. Biomed. Nanotechnol. 11 , 1608-27, (2015) The triple negative breast cancer (TNBCs) and non-small cell lung cancers (NSCLCs) often acquire mutations that contribute to failure of drugs in clinic and poor prognosis, thus presenting an urgent need to develop new and improved therapeutic modalities. Her... |
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Selective inhibition of carboxylesterases by isatins, indole-2,3-diones.
J. Med. Chem. 50 , 1876-85, (2007) Carboxylesterases (CE) are ubiquitous enzymes thought to be responsible for the metabolism and detoxification of xenobiotics. Numerous clinically used drugs including Demerol, lidocaine, capecitabine, and CPT-11 are hydrolyzed by these enzymes. Hence, the ide... |
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Conformationally constrained ortho-anilino diaryl ureas: discovery of 1-(2-(1'-neopentylspiro[indoline-3,4'-piperidine]-1-yl)phenyl)-3-(4-(trifluoromethoxy)phenyl)urea, a potent, selective, and bioavailable P2Y1 antagonist.
J. Med. Chem. 56(22) , 9275-95, (2013) Preclinical antithrombotic efficacy and bleeding models have demonstrated that P2Y1 antagonists are efficacious as antiplatelet agents and may offer a safety advantage over P2Y12 antagonists in terms of reduced bleeding liabilities. In this article, we descri... |
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Metal-free catalyzed oxidative trimerization of indoles by using TEMPO in air: a biomimetic approach to 2-(1H-indol-3-yl)-2,3'-biindolin-3-ones.
Org. Biomol. Chem. 10(44) , 8814-21, (2012) A simple, convenient and efficient metal-free catalyzed oxidative trimeric reaction of indoles toward a variety of 2-(1H-indol-3-yl)-2,3'-biindolin-3-one derivatives in moderate to excellent yields has been developed. This transformation proceeds via a tandem... |
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Efficient construction of highly functionalized spiro[γ-butyrolactone-pyrrolidin-3,3'-oxindole] tricyclic skeletons via an organocatalytic 1,3-dipolar cycloaddition.
Chem. Commun. (Camb.) 49(33) , 3458-60, (2013) Highly functionalized spiro[γ-butyrolactone-pyrrolidin-3,3'-oxindole] tricyclic skeletons were delivered successfully with high optical purity using an effective yet simple procedure. |
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Chiral aminophosphines as catalysts for enantioselective double-Michael indoline syntheses.
Molecules 17(5) , 5626-50, (2012) The bisphosphine-catalyzed double-Michael addition of dinucleophiles to electron-deficient acetylenes is an efficient process for the synthesis of many nitrogen-containing heterocycles. Because the resulting heterocycles contain at least one stereogenic cente... |
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Synthesis of 1,4-bis(indolin-1-ylmethyl)benzene derivatives and their structure-activity relationships for the interaction of human carbonic anhydrase isoforms I and II.
Bioorg. Med. Chem. 21(6) , 1477-82, (2013) Several 1,4-bis(indolin-1-ylmethyl)benzene-based compounds containing substituents such as five, six and seven cyclic derivatives on indeno part (9a-c) were prepared and tested against two members of the pH regulatory enzyme family, carbonic anhydrase (CA). T... |
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Efficient construction of fused indolines with a 2-quaternary center via an intramolecular Heck reaction with a low catalyst loading.
Org. Lett. 14(8) , 2066-9, (2012) An efficient construction of fused indolines with a 2-quaternary center through a palladium-catalyzed intramolecular Heck reaction of N-(2(2-halobenzoxyl)-2,3-disubstituted indoles is disclosed. This protocol provided a straightforward access to diverse fused... |