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杜鹃醇

杜鹃醇用途

杜鹃花醇可诱发白皮病。杜鹃花醇通过增加谷胱甘肽水平诱导羟基自由基的产生和黑素细胞的细胞毒性。杜鹃花醇是一种酚类化合物,可从大叶枫和白桦等植物中分离得到[1]。

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杜鹃醇名称

[ CAS 号 ]:
501-96-2

[ 中文名 ]:
杜鹃醇

[ 英文名 ]:
Rhododendrol

[英文别名 ]:

4-[(3R)-3-Hydroxybutyl]phenol
Benzenepropanol, 4-hydroxy-α-methyl-
4-(3-Hydroxybutyl)phenol
4-(p-Hydroxyphenyl)-2-butanol
Benzenepropanol, 4-hydroxy-α-methyl-, (R)-
Benzenepropanol, 4-hydroxy-α-methyl-, (αR)-
2-Butanol, 4-(p-hydroxyphenyl)-
UNII:12QWN45UL0
Rhododendrol
(-)-Rhododendrol

杜鹃醇生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 炎症/免疫

[参考文献]

[1]. Gabe Y, et al. Substantial evidence for the rhododendrol-induced generation of hydroxyl radicals that causes melanocyte cytotoxicity and induces chemical leukoderma. J Dermatol Sci. 2018 Sep;91(3):311-316.

杜鹃醇物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
315.4±17.0 °C at 760 mmHg

[ 分子式 ]:
C₁₀H₁₄O₂

[ 分子量 ]:
166.22

[ 闪点 ]:
153.4±15.5 °C

[ 精确质量 ]:
166.099380

[ PSA ]:
40.46000

[ LogP ]:
1.49

[ 外观性状 ]:
粉末

[ 蒸汽压 ]:
0.0±0.7 mmHg at 25°C

[ 折射率 ]:
1.552

[ 储存条件 ]:
?20°C

杜鹃醇MSDS

详细MSDS(安全技术说明书)

杜鹃醇安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H319

[ 警示性声明 ]:
P305 + P351 + P338

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
22-36

[ 安全声明 (欧洲) ]:
26

[ 危险品运输编码 ]:
NONH for all modes of transport

杜鹃醇文献

T-Cell Responses to Tyrosinase-Derived Self-Peptides in Patients with Leukoderma Induced by Rhododendrol: Implications for Immunotherapy Targeting Melanoma.

Dermatology 232 , 44-9, (2016)

Rhododendrol, a phenolic compound contained in lightening/whitening cosmetics, can bind and inhibit tyrosinase and was reported to induce leukoderma in Japan. Only 2% of the cosmetics users are affect...

Rhododendrol, a depigmentation-inducing phenolic compound, exerts melanocyte cytotoxicity via a tyrosinase-dependent mechanism.

Pigment Cell Melanoma Res. 27(5) , 754-63, (2014)

Rhododendrol, an inhibitor of melanin synthesis developed for lightening/whitening cosmetics, was recently reported to induce a depigmentary disorder principally at the sites of repeated chemical cont...

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杜鹃醇