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N-碘代丁二酰亚胺

N-碘代丁二酰亚胺用途

【用途一】
主要作为生物制药中的医药中间体
【用途二】
在有机合成中用于酮类、醛类的碘化。
【用途三】
用于有机合成，硫的氧化滴定试剂，用作温和的碘化剂、硫苷催化剂等。

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N-碘代丁二酰亚胺名称

[ CAS 号 ]:
516-12-1

[ 中文名 ]:
N-碘代丁二酰亚胺

[ 英文名 ]:
N-iodosuccinimide

[中文别名 ]:

[英文别名 ]:

succinimide, N-iodo-
N-Iodosuccinimide
1-Iodopyrrolidine-2,5-dione
1-Iodo-2,5-pyrrolidinedione
N-Iodo succinimide
NIS
2,5-Pyrrolidinedione, 1-iodo-
N-Iodosuccinimide (NIS)
MFCD00005512
EINECS 208-221-6

N-碘代丁二酰亚胺物理化学性质

[ 密度 ]:
2.3±0.1 g/cm3

[ 沸点 ]:
249.6±23.0 °C at 760 mmHg

[ 熔点 ]:
202-206 °C(lit.)

[ 分子式 ]:
C₄H₄INO₂

[ 分子量 ]:
224.984

[ 闪点 ]:
104.8±22.6 °C

[ 精确质量 ]:
224.928665

[ PSA ]:
37.38000

[ LogP ]:
-0.21

[ 外观性状 ]:
白色至灰白色粉末

[ 蒸汽压 ]:
0.0±0.5 mmHg at 25°C

[ 折射率 ]:
1.653

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
decomposes

N-碘代丁二酰亚胺MSDS

N-碘代丁二酰亚胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WN2817000

CHEMICAL NAME :: Succinimide, N-iodo-

CAS REGISTRY NUMBER :: 516-12-1

BEILSTEIN REFERENCE NO. :: 0113917

LAST UPDATED :: 199709

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C4-H4-I-N-O2

MOLECULAR WEIGHT :: 224.99

WISWESSER LINE NOTATION :: T5VNVTJ BI

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 180 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#02815

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N-碘代丁二酰亚胺安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R22;R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36-S37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
WN2817000

[ 海关编码 ]:
29251995

N-碘代丁二酰亚胺合成路线

N-碘代丁二酰亚胺上下游产品

N-碘代丁二酰亚胺上游产品

N-碘代丁二酰亚胺下游产品

N-碘代丁二酰亚胺制备

1.在避光条件下，使丁二酰亚胺与氧化银反应，制取N-丁二亚胺银。将其和碘在干燥的二氧六环中反应，生成N-碘琥珀酰亚胺。

2. 在广口、螺旋盖的容量150一200毫升的棕色瓶中放20克(0.079摩尔)碘和90毫升干燥二氧六环，大部分碘溶解。加入18克(0.087摩尔)彻底干燥过的N一丁二酞亚胺银。把瓶激烈摇荡几分钟，在以后1小时内不时把混合物摇荡，然后在50℃水浴中加热5分钟。经过布氏漏斗趁热滤入用黑色纸或铝箔很好包裹好的幼。毫升滤瓶中。收集碘化银，用10毫升热的二氧六环洗涤。在滤瓶内合并滤液，加入200毫升四氯化碳，让溶液在一8℃至一20℃冷却过夜，N一碘丁二酸亚胺即成无色晶体析出。在尽可能少地暴露于光线的条件下收集在布氏漏斗中，用25毫升四氯化碳洗涤，吸滤使之干燥。在暗处25℃/1m rn干燥过夜。N一碘丁二酞亚胺重14.3-15.1克(81一85%)，

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N-碘代丁二酰亚胺海关

[ 海关编码 ]: 2925190090

[ 中文概述 ]:
2925190090 其他酰亚胺及其衍生物盐. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2925190090 other imides and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

N-碘代丁二酰亚胺文献

Phenotype and function of nasal dendritic cells.

Mucosal Immunol. 8 , 1083-98, (2015)

Intranasal (i.n.) vaccination generates immunity across local, regional, and distant sites. However, nasal dendritic cells (DCs), pivotal for the induction of i.n. vaccine-induced immune responses, ha...

Reduced parasite motility and micronemal protein secretion by a p38 MAPK inhibitor leads to a severe impairment of cell invasion by the apicomplexan parasite Eimeria tenella.

PLoS ONE 10(2) , e0116509, (2015)

E. tenella infection is associated with a severe intestinal disease leading to high economic losses in poultry industry. Mitogen activated protein kinases (MAPKs) are implicated in early response to i...

Differential expression of CART in feeding and reward circuits in binge eating rat model.

Behav. Brain Res. 291 , 219-31, (2015)

Binge eating (BE) disrupts feeding and subverts reward mechanism. Since cocaine- and amphetamine-regulated transcript peptide (CART) mediates satiety as well as reward, its role in BE justifies invest...

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N-碘代丁二酰亚胺

N-碘代丁二酰亚胺用途

N-碘代丁二酰亚胺名称

N-碘代丁二酰亚胺物理化学性质

N-碘代丁二酰亚胺MSDS

详细MSDS(安全技术说明书)

N-碘代丁二酰亚胺毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

N-碘代丁二酰亚胺安全信息

N-碘代丁二酰亚胺合成路线

详细合成路线

N-碘代丁二酰亚胺上下游产品

N-碘代丁二酰亚胺上游产品

N-碘代丁二酰亚胺下游产品

N-碘代丁二酰亚胺制备

N-碘代丁二酰亚胺海关

N-碘代丁二酰亚胺文献

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