马萘雌甾酮

马萘雌甾酮用途

Equilenin is an equine estrogen found in the urine of pregnant mares. Equilenin is also a naturally fluorescent steroid, has high binding affinity for human sex steroid-binding protein (SBP). At 4 degrees C the equilibrium association constant is approximately 6 X 10(7) M-1.

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马萘雌甾酮名称

[ CAS 号 ]:
517-09-9

[ 中文名 ]:
马萘雌甾酮

[ 英文名 ]:
equilenin

[中文别名 ]:

雌马甾酮

[英文别名 ]:

Equilenin solution
EQU
Equilenina
d-Equilenin

马萘雌甾酮物理化学性质

[ 密度 ]:
1.242g/cm3

[ 沸点 ]:
472.6ºC at 760mmHg

[ 熔点 ]:
258-259°

[ 分子式 ]:
C₁₈H₁₈O₂

[ 分子量 ]:
266.33400

[ 闪点 ]:
200.9ºC

[ 精确质量 ]:
266.13100

[ PSA ]:
37.30000

[ LogP ]:
3.94440

[ 折射率 ]:
1.662

马萘雌甾酮毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KG6125000

CHEMICAL NAME :: Estra-1,3,5,7,9-pentaen-17-one, 3-hydroxy-

CAS REGISTRY NUMBER :: 517-09-9

BEILSTEIN REFERENCE NO. :: 2335367

LAST UPDATED :: 199709

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C18-H18-O2

MOLECULAR WEIGHT :: 266.36

WISWESSER LINE NOTATION :: L E5 B666 FVTT&&J E1 OQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Implant

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 1600 ug/kg

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Reproductive - Tumorigenic effects - uterine tumors

REFERENCE :: BSBSAS Boletin de la Sociedad de Biologia de Santiago de Chile. (Santiago, Chile) V.1-12, 1943-55. Discontinued. Volume(issue)/page/year: 8,142,1951

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Implant

SPECIES OBSERVED :: Rodent - hamster

DOSE/DURATION :: 640 mg/kg/38W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, Bladder - Kidney tumors

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 43,5200,1983

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Implant

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 17 mg/kg

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Reproductive - Tumorigenic effects - uterine tumors

REFERENCE :: RBBIAL Revista Brasileira de Biologia. Brazilian Review of Biology. (Academia Brasileira de Ciencias, Caixa Postal 229, ZC-00 Rio de Janeiro, Brazil) V.1- 1941- Volume(issue)/page/year: 5,1,1945

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马萘雌甾酮安全信息

[ 符号 ]:

GHS02, GHS07

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H302-H312-H319-H332

[ 警示性声明 ]:
P210-P280-P305 + P351 + P338

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
F,Xn

[ 风险声明 (欧洲) ]:
11-20/21/22-36

[ 安全声明 (欧洲) ]:
16-26-36-36/37

[ 危险品运输编码 ]:
UN 1648 3/PG 2

马萘雌甾酮合成路线

详细合成路线

马萘雌甾酮上下游产品

马萘雌甾酮上游产品

马萘雌甾酮下游产品

马萘雌甾酮文献

Development of a liquid chromatography electrospray ionization tandem mass spectrometry method for analysis of stable 4-hydroxyequilenin-DNA adducts in human breast cancer cells.

Chem. Res. Toxicol. 22(6) , 1129-36, (2009)

Estrogen-DNA adducts are potential biomarkers for assessing cancer risk and progression in estrogen-dependent cancer. 4-Hydroxyequilenin (4-OHEN), the major catechol metabolite of equine estrogens pre...

Activation of estrogen receptor-mediated gene transcription by the equine estrogen metabolite, 4-methoxyequilenin, in human breast cancer cells.

Endocrinology 148(10) , 4793-802, (2007)

4-Methoxyequilenin (4-MeOEN) is an O-methylated metabolite in equine estrogen metabolism. O-methylation of catechol estrogens is considered as a protective mechanism; however, comparison of the proper...

Mechanism of translesion synthesis past an equine estrogen-DNA adduct by Y-family DNA polymerases.

J. Mol. Biol. 371(5) , 1151-62, (2007)

4-Hydroxyequilenin (4-OHEN)-dC is a major, potentially mutagenic DNA adduct induced by equine estrogens used for hormone replacement therapy. To study the miscoding property of 4-OHEN-dC and the invol...

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