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马烯雌酮

马烯雌酮用途

Equilin是从马尿中分离的雌激素混合物中的一种雌激素。

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马烯雌酮名称

[ CAS 号 ]:
474-86-2

[ 中文名 ]:
马烯雌甾酮

[ 英文名 ]:
Equilin

[中文别名 ]:

氟哌噻吨

[英文别名 ]:

Equilin
Estra-1,3,5(10),7-tetraen-17-one, 3-hydroxy-
3-Hydroxyestra-1,3,5(10),7-tetraen-17-one (9CI)
Dihydroequilenin
3-Hydroxyestra-1,3,5(10),7-tetraen-17-one
1,3,5,7-Estratetraen-3-ol-17-one
7-Dehydroestrone

马烯雌酮生物活性

[ 描述 ]:

Equilin是从马尿中分离的雌激素混合物中的一种雌激素。

[ 相关类别 ]:

信号通路 >> 其他 >> 雌激素受体/ERR

研究领域 >> 内分泌

[相关活性小分子]

马烯雌酮物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
459.1±45.0 °C at 760 mmHg

[ 熔点 ]:
238-240ºC(lit.)

[ 分子式 ]:
C₁₈H₂₀O₂

[ 分子量 ]:
268.350

[ 闪点 ]:
195.4±21.3 °C

[ 精确质量 ]:
268.146332

[ PSA ]:
37.30000

[ LogP ]:
3.53

[ 蒸汽压 ]:
0.0±1.2 mmHg at 25°C

[ 折射率 ]:
1.626

[ 储存条件 ]:
-20°C

马烯雌酮MSDS

详细MSDS(安全技术说明书)

马烯雌酮毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KG6650000

CHEMICAL NAME :: Estra-1,3,5(10),7-tetraen-17-one, 3-hydroxy-

CAS REGISTRY NUMBER :: 474-86-2

BEILSTEIN REFERENCE NO. :: 2624302

LAST UPDATED :: 199709

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C18-H20-O2

MOLECULAR WEIGHT :: 268.38

WISWESSER LINE NOTATION :: L E5 B666 FV JUTTT&J E1 OQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 112 mg/kg/56W-I

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Skin and Appendages - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Implant

SPECIES OBSERVED :: Rodent - hamster

DOSE/DURATION :: 640 mg/kg/38W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, Bladder - Kidney tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 168 mg/kg/42W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 400 mg/kg

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 48,14,1988

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马烯雌酮安全信息

[ 符号 ]:

GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H351-H360-H362

[ 警示性声明 ]:
P201-P260-P263-P280-P308 + P313

[ 个人防护装备 ]:
Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R40

[ 安全声明 (欧洲) ]:
36/37-45-16-7

[ 危险品运输编码 ]:
UN1230 - class 3 - PG 2 - Methanol, solution

[ WGK德国 ]:
3

[ RTECS号 ]:
KG6650000

马烯雌酮合成路线

详细合成路线

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马烯雌酮上游产品

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马烯雌酮文献

An updated steroid benchmark set and its application in the discovery of novel nanomolar ligands of sex hormone-binding globulin.

J. Med. Chem. 51 , 2047-56, (2008)

A benchmark data set of steroids with known affinity for sex hormone-binding globulin (SHBG) has been widely used to validate popular molecular field-based QSAR techniques. We have expanded the data s...

Potent and selective steroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 7, an enzyme that catalyzes the reduction of the key hormones estrone and dihydrotestosterone.

J. Med. Chem. 52 , 7488-502, (2009)

17beta-Hydroxysteroid dehydrogenase type 7 (17beta-HSD7) catalyzes the reduction of estrone (E(1)) into estradiol (E(2)) and of dihydrotestosterone (DHT) into 5alpha-androstane-3beta,17beta-diol (3bet...

Comparison of the proliferative effects of estradiol and conjugated equine estrogens on human breast cancer cells and impact of continuous combined progestogen addition.

Climacteric 6(3) , 221-7, (2003)

So far, most epidemiological studies investigating breast cancer risk and hormone replacement therapy have been conducted with conjugated equine estrogens (CEE). Recent trials indicate that the additi...

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