环香豆素

环香豆素用途

Cyclocumarol is an anticoagulant similar to but less potent than warfarin. This product may cause hemorrhaging if used indiscriminately.

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环香豆素名称

[ CAS 号 ]:
518-20-7

[ 中文名 ]:
环香豆素

[ 英文名 ]:
pyranocoumarin

[中文别名 ]:

吡喃香豆素

[英文别名 ]:

Pyranocumarin [German]
Cumopyran
Compound 63 link
CYCLOCUMAROL
Methanopyranorin
Cyclocoumarol
Anticoagulans 63
BL 5
Cumopyrin
Pyranocoumarin

环香豆素物理化学性质

[ 密度 ]:
1.27g/cm3

[ 沸点 ]:
488.6ºC at 760 mmHg

[ 熔点 ]:
166°

[ 分子式 ]:
C₂₀H₁₈O₄

[ 分子量 ]:
322.35500

[ 闪点 ]:
216.2ºC

[ 精确质量 ]:
322.12100

[ PSA ]:
48.67000

[ LogP ]:
4.07000

[ 折射率 ]:
1.624

环香豆素毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UQ0335200

CHEMICAL NAME :: 2H,5H-Pyrano(3,2-c)(1)benzopyran-5-one, 3,4-dihydro-2-methoxy-2-methyl-4-phenyl-

CAS REGISTRY NUMBER :: 518-20-7

LAST UPDATED :: 199409

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C20-H18-O4

MOLECULAR WEIGHT :: 322.38

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85ARAE "Agricultural Chemicals," Thomson, W.T., 4 vols., Fresno, CA, Thomson Publications, 1976/77 revision Volume(issue)/page/year: 3,142,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 21 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85JFAN "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc. of Chemistry, 1983-86 Volume(issue)/page/year: A355,1983

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: SMWOAS Schweizerische Medizinische Wochenschrift. (Schwabe & Co., Steintorst 13, 4010 Basel, Switzerland) V.50- 1920- Volume(issue)/page/year: 83,471,1953

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: SMWOAS Schweizerische Medizinische Wochenschrift. (Schwabe & Co., Steintorst 13, 4010 Basel, Switzerland) V.50- 1920- Volume(issue)/page/year: 83,471,1953

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环香豆素安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H310

[ 警示性声明 ]:
P262-P280-P302 + P352 + P310-P361 + P364

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T+

[ 风险声明 (欧洲) ]:
27

[ 安全声明 (欧洲) ]:
28-36/37-45

[ 危险品运输编码 ]:
UN 2811

[ RTECS号 ]:
UQ0335200

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

[ 海关编码 ]:
2932999099

环香豆素海关

[ 海关编码 ]: 2932999099

[ 中文概述 ]:
2932999099. 其他仅含氧杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

环香豆素文献

The preferred solution conformation of warfarin at the active site of cytochrome P-450 based on the CD spectra in octanol/water model system.

J. Med. Chem. 27(8) , 1092-5, (1984)

An octanol/water model system and circular dichroism (CD) spectroscopy have been used to study the solution conformation of warfarin in aqueous and lipid environments. Upon partitioning of (S)-warfari...

Structural forms of phenprocoumon and warfarin that are metabolized at the active site of CYP2C9.

Arch. Biochem. Biophys. 372(1) , 16-28, (1999)

Possible reasons for the observed differences in metabolic behavior and drug interaction liability between the structurally similar oral anticoagulants warfarin and phenprocoumon were explored. Incuba...

Inhibitory effect of coumarins on HIV-1 replication and cell-mediated or cell-free viral transmission.

Acta Virol. 37(4) , 241-50, (1993)

A single dose of coumarin derivatives, warfarin, 4-hydroxycoumarin and umbelliferone, added at the time of inoculation either by free virus or by contact with U1 monocytes exhibited a dose-dependent i...

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