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美雄诺龙

美雄诺龙用途

用于慢性消耗性疾病、骨质疏松症、严重感染和创伤烧伤等引起的负氮平衡，促进早产儿及未成熟儿的生长等．对骨折不易愈合、高胆固醇血症、产后衰弱等亦可使用。

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美雄诺龙名称

[ CAS 号 ]:
521-11-9

[ 中文名 ]:
17α-甲基雄甾-17β-醇-3-酮

[ 英文名 ]:
Mestanolone

[中文别名 ]:

美雄诺龙

[英文别名 ]:

17a-Methylandrostan-17b-ol-3-one
Anabo
Tantaron
17b-Hydroxy-17-methyl-5a-androstan-3-one
17a-Methylandrostan-3-on-17b-ol
EINECS 208-302-6
5α-Androstan-3-one, 17β-hydroxy-17-methyl-
Assimil
Preroide
Androstan-3-one, 17-hydroxy-17-methyl-, (5α,17β)-

美雄诺龙物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
416.1±38.0 °C at 760 mmHg

[ 熔点 ]:
191 °C

[ 分子式 ]:
C₂₀H₃₂O₂

[ 分子量 ]:
304.467

[ 闪点 ]:
177.6±19.4 °C

[ 精确质量 ]:
304.240234

[ PSA ]:
37.30000

[ LogP ]:
4.29

[ 外观性状 ]:
白色至灰白色结晶粉末

[ 蒸汽压 ]:
0.0±2.2 mmHg at 25°C

[ 折射率 ]:
1.528

[ 储存条件 ]:
Controlled Substance, -20?C Freezer

美雄诺龙MSDS

美雄诺龙毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BV8064500

CHEMICAL NAME :: 5-alpha-Androstan-3-one, 17-beta-hydroxy-17-methyl-

CAS REGISTRY NUMBER :: 521-11-9

BEILSTEIN REFERENCE NO. :: 3207223

LAST UPDATED :: 199612

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C20-H32-O2

MOLECULAR WEIGHT :: 304.52

WISWESSER LINE NOTATION :: L E5 B666 OVTJ A1 E1 FQ F1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >3 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,817,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,817,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,817,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >3 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,817,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1240 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,817,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,817,1982 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 160 mg/kg

SEX/DURATION :: female 14-21 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - urogenital system

REFERENCE :: ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21203) V.1- 1917- Volume(issue)/page/year: 94,979,1974

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美雄诺龙安全信息

[ 符号 ]:

GHS08

[ 信号词 ]:
Warning

[ 危害声明 ]:
H351

[ 警示性声明 ]:
P281

[ 个人防护装备 ]:
Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
R40

[ 安全声明 (欧洲) ]:
S22-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
BV8064500

[ 海关编码 ]:
2937290017

美雄诺龙合成路线

美雄诺龙制备

用17α-甲基-3,17β-雄甾烷二醇经铬酸氧化制得。

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美雄诺龙海关

[ 海关编码 ]: 2937290017

美雄诺龙文献

An updated steroid benchmark set and its application in the discovery of novel nanomolar ligands of sex hormone-binding globulin.

J. Med. Chem. 51 , 2047-56, (2008)

A benchmark data set of steroids with known affinity for sex hormone-binding globulin (SHBG) has been widely used to validate popular molecular field-based QSAR techniques. We have expanded the data s...

Inhibitory effect and interaction of stanozolol with pig testicular cytochrome P-450 (17 alpha-hydroxylase/C17,20-lyase).

Chem. Pharm. Bull. 37(7) , 1855-8, (1989)

The inhibitory effect of an anabolic steroid, stanozolol, on testicular microsomal cytochrome P-450 (17 alpha-hydroxylase/C17,20-lyase) (P-450(17 alpha/lyase] and the nature of the interaction were co...

Chemometric and chemoinformatic analyses of anabolic and androgenic activities of testosterone and dihydrotestosterone analogues.

Bioorg. Med. Chem. 16 , 6448-59, (2008)

Predictive quantitative structure-activity relationship (QSAR) models of anabolic and androgenic activities for the testosterone and dihydrotestosterone steroid analogues were obtained by means of mul...

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美雄诺龙

美雄诺龙用途

美雄诺龙名称

美雄诺龙物理化学性质

美雄诺龙MSDS

详细MSDS(安全技术说明书)

美雄诺龙毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

美雄诺龙安全信息

美雄诺龙合成路线

详细合成路线

美雄诺龙制备

美雄诺龙海关

美雄诺龙文献

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