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N-琥珀酰-L-丙氨酰-L-丙氨酰-L-丙氨酸

N-琥珀酰-L-丙氨酰-L-丙氨酰-L-丙氨酸用途

弹性蛋白酶底物。

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N-琥珀酰-L-丙氨酰-L-丙氨酰-L-丙氨酸名称

[ CAS 号 ]:
52299-14-6

[ 中文名 ]:
Suc-丙氨酰-丙氨酰-丙氨酰-对硝基苯胺

[ 英文名 ]:
Suc-Ala-Ala-Ala-pNA

[中文别名 ]:

[英文别名 ]:

EINECS 257-823-5
MFCD00036774

N-琥珀酰-L-丙氨酰-L-丙氨酰-L-丙氨酸生物活性

[ 描述 ]:

Suc-AAA-pNA 是猪胰腺弹性酶 (PPE) 可逆抑制分析的底物。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[ 靶点 ]

IC50: Substrate[1]

[参考文献]

[1]. Panagiota-Yiolanda Stergiou, et al. Kinetic and computational analysis of the reversible inhibition of porcine pancreatic elastase: a structural and mechanistic approach. J Enzyme Inhib Med Chem. 2016;31(sup3):131-139.

N-琥珀酰-L-丙氨酰-L-丙氨酰-L-丙氨酸物理化学性质

[ 密度 ]:
1.37 g/cm3

[ 沸点 ]:
923.5ºC at 760 mmHg

[ 分子式 ]:
C₁₉H₂₅N₅O₈

[ 分子量 ]:
451.43

[ 闪点 ]:
512.3ºC

[ 精确质量 ]:
451.17000

[ PSA ]:
199.52000

[ LogP ]:
1.68110

[ 外观性状 ]:
白色固体

[ 折射率 ]:
1.584

[ 储存条件 ]:
2-8°C

N-琥珀酰-L-丙氨酰-L-丙氨酰-L-丙氨酸安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 安全声明 (欧洲) ]:
24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
29242990

N-琥珀酰-L-丙氨酰-L-丙氨酰-L-丙氨酸合成路线

详细合成路线

N-琥珀酰-L-丙氨酰-L-丙氨酰-L-丙氨酸上下游产品

N-琥珀酰-L-丙氨酰-L-丙氨酰-L-丙氨酸上游产品

N-琥珀酰-L-丙氨酰-L-丙氨酰-L-丙氨酸下游产品

N-琥珀酰-L-丙氨酰-L-丙氨酰-L-丙氨酸文献

A new Kunitz-type plasmin inhibitor from scorpion venom.

Toxicon 106 , 7-13, (2015)

Kunitz-type peptides from venomous animals are an important source of lead drug candidates towards human plasmin, a target of protease-associated diseases. However, no Kunitz-type plasmin inhibitor fr...

SjAPI, the first functionally characterized Ascaris-type protease inhibitor from animal venoms.

PLoS ONE 8(3) , e57529, (2013)

Serine protease inhibitors act as modulators of serine proteases, playing important roles in protecting animal toxin peptides from degradation. However, all known serine protease inhibitors discovered...

Purification, kinetical and molecular characterizations of a serine collagenolytic protease from greenshore crag (Carcinus maenas) digestive gland.

Comp. Biochem. Physiol. B Biochem. Mol. Biol. 115(1) , 87-95, (1996)

A serine collagenolytic protease was purified from a water soluble fraction of greenshore crab digestive gland by acidic precipitation, gel filtration on a Sephadex G-50 column, ion-exchange chromatog...

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