丁二酸酐

丁二酸酐用途

Succinic anhydride 是一种环酐和 ADC 连接桥 (ADC linker),详细信息可参考专利 WO2009064913A1。Succinic anhydride 与专利中的化合物 4 反应,可将前药连接到靶向多肽的胺或羟基 1。

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丁二酸酐名称

[ CAS 号 ]:
108-30-5

[ 中文名 ]:
丁二酸酐

[ 英文名 ]:
Succinic anhydride

[中文别名 ]:

[英文别名 ]:

SAN
3,4-dihydrofuran-2,5-dione
succinylanhydride
Dihydrofuran-2,5-dione
dihydro-furan-2.5-dione
succinic acid anhydride
tetrahydrofuran-2,5-dione
Oxolan-2,5-dione
SAA
Succinic Anhydride

丁二酸酐生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 抗体- 药物偶联物 >> ADC连接器

[ 靶点 ]

Alkyl/ether

[参考文献]

[1]. Dale Boger.et al. Chimer containing a targeting portion linked to a scission-activated duocarmycin-type prodrug. WO2009064913A1.

丁二酸酐物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
261.0±0.0 °C at 760 mmHg

[ 熔点 ]:
118-120 °C(lit.)

[ 分子式 ]:
C₄H₄O₃

[ 分子量 ]:
100.073

[ 闪点 ]:
122.1±15.9 °C

[ 精确质量 ]:
100.016045

[ PSA ]:
43.37000

[ LogP ]:
-1.30

[ 外观性状 ]:
细白色结晶固体

[ 蒸汽密度 ]:
3.5 (vs air)

[ 蒸汽压 ]:
0.0±0.5 mmHg at 25°C

[ 折射率 ]:
1.470

[ 储存条件 ]:
Store at 0-5°C

[ 稳定性 ]:
Stable. Incompatible with oxidising agents, strong acids, strong bases, alcohols, amines. Avoid exposure to water or moisture.

[ 水溶解性 ]:
<0.1 g/100 mL at 21 ºC (decomposes)

丁二酸酐MSDS

丁二酸酐毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WN0875000

CHEMICAL NAME :: Succinic anhydride

CAS REGISTRY NUMBER :: 108-30-5

BEILSTEIN REFERENCE NO. :: 0108441

LAST UPDATED :: 199710

DATA ITEMS CITED :: 22

MOLECULAR FORMULA :: C4-H4-O3

MOLECULAR WEIGHT :: 100.08

WISWESSER LINE NOTATION :: T5VOVTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1510 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 13 gm/kg/13W-I

TOXIC EFFECTS :: Liver - changes in liver weight Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2618 mg/kg/20D-I

TOXIC EFFECTS :: Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 10500 mg/kg/16D-I

TOXIC EFFECTS :: Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 19500 mg/kg/13W-I

TOXIC EFFECTS :: Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2600 mg/kg/65W-I

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Tumorigenic - tumors at site of application

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 79 mg/kg

SEX/DURATION :: female 8-10 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - other developmental abnormalities

MUTATION DATA

TYPE OF TEST :: Morphological transformation

TEST SYSTEM :: Rodent - hamster Embryo

DOSE/DURATION :: 100 ug/L

REFERENCE :: IJCNAW International Journal of Cancer. (International Union Against Cancer, 3 rue du Conseil- General, 1205 Geneva, Switzerland) V.1- 1966- Volume(issue)/page/year: 19,642,1977 *** REVIEWS *** IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 15,265,1977 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 15,265,1977 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4008 No. of Facilities: 263 (estimated) No. of Industries: 7 No. of Occupations: 5 No. of Employees: 3059 (estimated) No. of Female Employees: 1207 (estimated)

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丁二酸酐安全信息

[ 符号 ]:

GHS05, GHS07, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H302-H314-H317-H334-H335

[ 警示性声明 ]:
P260-P280-P284-P303 + P361 + P353-P304 + P340 + P310-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R22;R36/37

[ 安全声明 (欧洲) ]:
S25

[ 危险品运输编码 ]:
UN 3261 8 / PGII

[ WGK德国 ]:
1

[ RTECS号 ]:
WN0875000

[ 海关编码 ]:
2932999099

丁二酸酐合成路线

丁二酸酐上下游产品

丁二酸酐上游产品

丁二酸酐下游产品

丁二酸酐制备

3. 烟草：OR，18。

4. 从绝对乙醇中得正交形棱晶。

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丁二酸酐海关

[ 海关编码 ]: 2917190090

[ 中文概述 ]:
2917190090 其他无环多元羧酸. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 对苯二甲酸请注明4-CBA值, 对苯二甲酸请注明P-TL酸值, 对苯二甲酸请注明色度, 对苯二甲酸请注明水分

[ Summary ]:
2917190090 acyclic polycarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

丁二酸酐文献

Synthesis of PS/PO-chimeric oligonucleotides using mixed oxathiaphospholane and phosphoramidite chemistry.

Org. Biomol. Chem. 13(1) , 269-76, (2014)

Chimeric oligonucleotides containing phosphodiester and phosphorothioate linkages have been obtained using the solid phase synthesis. The oligonucleotide parts possessing natural internucleotide phosp...

Quantification of Sorafenib in Human Serum by Competitive Enzyme-Linked Immunosorbent Assay.

Biol. Pharm. Bull. 38 , 1788-93, (2015)

The multikinase inhibitor sorafenib has been used in the treatment of hepatocellular carcinoma, renal cell carcinoma, and differentiated thyroid carcinoma. Here we have demonstrated the production of ...

Iron Oxide and Titanium Dioxide Nanoparticle Effects on Plant Performance and Root Associated Microbes.

Int. J. Mol. Sci. 16 , 23630-50, (2015)

In this study, we investigated the effect of positively and negatively charged Fe₃O₄ and TiO₂ nanoparticles (NPs) on the growth of soybean plants (Glycine max.) and their root associated soil microbes...

更多文献

丁二酸酐

丁二酸酐用途

丁二酸酐名称

丁二酸酐生物活性

丁二酸酐物理化学性质

丁二酸酐MSDS

详细MSDS(安全技术说明书)

丁二酸酐毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

丁二酸酐安全信息

丁二酸酐合成路线

详细合成路线

丁二酸酐上下游产品

丁二酸酐上游产品

丁二酸酐下游产品

丁二酸酐制备

丁二酸酐海关

丁二酸酐文献

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