吡哆胺5 '磷酸盐

吡哆胺5 '磷酸盐用途

5′-磷酸吡哆胺是维生素B6与磷酸结合的活性形式。5′-磷酸吡哆胺是5′-磷酸酯吡哆醛水合物(HY-W011727A)的胺化形式,是多种酶的辅因子,中枢代谢物、强效抗氧化剂、维生素B6维生素和酶底物。5’-磷酸吡哆醛可以与水合5’-磷酸吡哆醛相互转化[1]。

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吡哆胺5 '磷酸盐名称

[ CAS 号 ]:
529-96-4

[ 中文名 ]:
吡哆胺-5′-磷酸盐

[ 英文名 ]:
pyridoxamine phosphate

[英文别名 ]:

Pyridoxamine,3-(dihydrogen phosphate)
pyrodoxylamine-5'-phosphate
Pyridoxamine phosphate [JAN]
pyridoxamine phosphate
Pyridoxamine-P
Pyridoxamine,dihydrogen phosphate

吡哆胺5 '磷酸盐生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 神经疾病

[ 靶点 ]

Human Endogenous Metabolite

[体外研究]

5′-磷酸吡哆醛可以转化为5′-磷酸吡哆胺。在(S)-α-甲基苄胺(MBA)作为胺供体的情况下,从紫杆菌纯化的His标记的omega TA CV2025能够将5′-磷酸吡哆醛完全转化为5′-磷酸盐吡哆胺。

[参考文献]

[1]. Seo JH, et, al. Necessary and sufficient conditions for the asymmetric synthesis of chiral amines using ω-aminotransferases. Biotechnol Bioeng. 2011 Feb;108(2):253-63.

吡哆胺5 '磷酸盐物理化学性质

[ 密度 ]:
1.559g/cm3

[ 沸点 ]:
607.3ºC at 760 mmHg

[ 分子式 ]:
C₈H₁₃N₂O₅P

[ 分子量 ]:
248.17300

[ 闪点 ]:
321.1ºC

[ 精确质量 ]:
248.05600

[ PSA ]:
135.71000

[ LogP ]:
0.86390

[ 折射率 ]:
1.622

[ 储存条件 ]:
室温，干燥，密封

吡哆胺5 '磷酸盐MSDS

吡哆胺5 '磷酸盐毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UT4710000

CHEMICAL NAME :: 3-Pyridinemethanol, 4-(aminomethyl)-5-hydroxy-6-methyl-, alpha-(dihydrogen phosphate)

CAS REGISTRY NUMBER :: 529-96-4

BEILSTEIN REFERENCE NO. :: 0233653

LAST UPDATED :: 199612

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C8-H13-N2-O5-P

MOLECULAR WEIGHT :: 248.20

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >7500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,895,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 6300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,895,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 610 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,895,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,895,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3700 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,895,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,895,1990

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吡哆胺5 '磷酸盐安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
36/37/38

[ 安全声明 (欧洲) ]:
26

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
UT4710000

[ 海关编码 ]:
2933399090

吡哆胺5 '磷酸盐合成路线

吡哆胺5 '磷酸盐上下游产品

吡哆胺5 '磷酸盐上游产品

吡哆胺5 '磷酸盐下游产品

吡哆胺5 '磷酸盐海关

[ 海关编码 ]: 2933399090

[ 中文概述 ]:
2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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