苯甲酸钠_MSDS_用途_密度_苯甲酸钠CAS号【532-32-1】

苯甲酸钠可用作辅料,如抗菌剂、防腐剂、润滑剂等。药用辅料,或称药用辅料,是指除药物成分外,在制药过程中使用的其他化学物质。药用辅料一般是指药物制剂中的非活性成分,可以提高药物制剂的稳定性、溶解性和加工性。药用赋形剂还影响共同给药药物的吸收、分布、代谢和消除(ADME)过程[1]。

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[ 描述 ]:

苯甲酸钠可用作辅料,如抗菌剂、防腐剂、润滑剂等。药用辅料,或称药用辅料,是指除药物成分外,在制药过程中使用的其他化学物质。药用辅料一般是指药物制剂中的非活性成分,可以提高药物制剂的稳定性、溶解性和加工性。药用赋形剂还影响共同给药药物的吸收、分布、代谢和消除(ADME)过程[1]。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Elder DP, et al. Pharmaceutical excipients - quality, regulatory and biopharmaceutical considerations. Eur J Pharm Sci. 2016 May 25;87:88-99.

[ 密度 ]:
1,44 g/cm3

[ 沸点 ]:
249.3ºC at 760 mmHg

[ 熔点 ]:
>300 °C(lit.)

[ 分子式 ]:
C₇H₅NaO₂

[ 分子量 ]:
144.10

[ 闪点 ]:
111.4ºC

[ 精确质量 ]:
144.018723

[ PSA ]:
40.13000

[ LogP ]:
0.05010

[ 外观性状 ]:
白色结晶粉末

[ 储存条件 ]:
库房低温,通风,干燥

[ 稳定性 ]:
Stable, but may be moisture senstive. Incompatible with strong oxidizing agents, alkalis, mineral acids.

[ 水溶解性 ]:
soluble

详细MSDS(安全技术说明书)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DH6650000

CHEMICAL NAME :: Benzoic acid, sodium salt

CAS REGISTRY NUMBER :: 532-32-1

LAST UPDATED :: 199710

DATA ITEMS CITED :: 30

MOLECULAR FORMULA :: C7-H5-O2.Na

MOLECULAR WEIGHT :: 144.11

WISWESSER LINE NOTATION :: QVR &-NA-

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4070 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1714 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1600 mg/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1440 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2306 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 1400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Amphibian - frog

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 27370 mg/kg/10D-C

TOXIC EFFECTS :: Liver - changes in liver weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Metabolism (Intermediary) - other proteins

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 84 gm/kg/28D-C

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Kidney, Ureter, Bladder - other changes Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 137 gm/kg/13W-C

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 45 gm/kg/10D-C

TOXIC EFFECTS :: Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 44 gm/kg

SEX/DURATION :: female 1-22 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - homeostasis Reproductive - Specific Developmental Abnormalities - eye/ear Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 44 gm/kg

SEX/DURATION :: female 1-22 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 3 gm/kg

SEX/DURATION :: female 12-14 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 300 mg/kg

SEX/DURATION :: female 12-14 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetal death

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Rodent - hamster Fibroblast

DOSE/DURATION :: 2 gm/L/48H

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 48,337,1977 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80214 No. of Facilities: 13289 (estimated) No. of Industries: 84 No. of Occupations: 69 No. of Employees: 92390 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1192 No. of Facilities: 31 (estimated) No. of Industries: 2 No. of Occupations: 2 No. of Employees: 430 (estimated) No. of Female Employees: 288 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80214 No. of Facilities: 20457 (estimated) No. of Industries: 143 No. of Occupations: 125 No. of Employees: 533161 (estimated) No. of Female Employees: 199915 (estimated)

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[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H319

[ 警示性声明 ]:
P305 + P351 + P338

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi:Irritant

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
1

[ RTECS号 ]:
DH6650000

[ 海关编码 ]:
4002191900

苯甲酸钠上游产品

苯甲酸钠下游产品

1.由苯甲酸与碳酸氢钠中和而得。将水和碳酸氢钠加入中和锅，加热至沸溶解成碳酸氢钠溶液。搅拌下投入苯甲酸，至反应液pH为7-7.5。加热使二氧化碳逸尽，加活性炭脱色半小时。抽滤，滤液浓缩后缓缓放入结片机液盘内，经滚筒干燥结片，粉碎，得苯甲酸钠。消耗定额苯甲酸（99.5%）1045kg/t、碳酸氢钠（98%）610kg/t。在中和锅中用32%的纯碱溶液将苯甲酸中和至Ph值为7.5，中和温度控制在70℃。中和液用0.3%的活性炭脱色后真空吸滤，滤液经浓缩、干燥即成粉状苯甲酸钠产品。
2. 甲苯氧化法　苯甲酸可由邻苯二甲酸酐水解、脱羧制得；亦可由甲苯氧化、水解制得；还可直接由甲液相氧化制得。苯甲酸再经Na2CO3中和即成钠盐。甲苯氧化法的反应式如下：

①甲苯氧化　将甲苯2200kg、萘酸钴2.2kg用泵送入氧化塔内（铝质，700mm×8000mm），通夹套蒸汽加热到120℃，此时甲苯沸腾。这时启动6.0m³的空压机，压缩空气经缓冲罐自塔的底部进入甲苯溶液中，发生氧化反应。该氧化反应是放热的，所以反应温度不断上升，但最高不能超过170℃。
因此中途塔夹套不仅要停止加热，而且要切换通水冷却。氧化反应时有大量甲苯蒸气及水蒸气从塔顶排出，进入20m²的蛇管冷凝器，冷凝成液体再进入分水器，甲苯由分水器上部返回氧化塔，水从分水器下部分出，然后进入计量槽。分水器上盖有尾气排出管，尾气经排出管至缓冲罐进入活性炭吸收塔，以吸附其中的甲苯。定时向塔内直接通蒸汽，以解吸被吸附的甲苯，后者经冷凝、分水、干燥后回收再用。甲苯在170℃氧化时间约12～16h，甲苯转化率可达70%以上。

②脱苯　氧化液放入脱苯釜（1500L，带夹套），在0.08MPa真空下通夹套蒸汽加热至100～110℃，用压缩空气鼓泡的办法将未反应的甲苯蒸出，进入10m²的冷凝器，冷凝液进入分水器回收再用。
③蒸馏　脱苯后的苯甲酸还含有杂质及有机色素，需再进行蒸馏。将料液放入蒸馏釜（搪瓷或不锈钢），加热并控制料液温度为190℃，苯甲酸便蒸出而进入蒸馏塔（270mm×6000mm，有7块塔板），控制塔顶温度为160℃，馏出物经套管冷却进入中和釜，便得到纯净的苯甲酸。
④中和　苯甲酸进入中和釜后，及时加入预先配好的纯碱溶液中和（300L蒸馏水加纯碱140kg，可中和苯甲酸200kg左右）。中和温度以70℃为宜，中和物料以pH值7.5为终点。为除杂色，按中和物料3%加入活性炭脱色，然后通过真空吸滤，即得无色透明的苯甲酸钠溶液（含量50%）。
⑤干燥　将苯甲酸钠溶液经滚筒干燥，或箱式喷雾干燥即成粉状成品。

3.苯甲酸甲酯与NaOH溶液反应制备　将减压精馏制得的苯甲酸甲酯加入四口烧瓶中，恒温水浴加热并控制温度，开启搅拌器，达到设定反应温度后用分液漏斗滴加一定浓度的NaOH溶液，生成甲醇及时蒸出，皂化反应制得苯甲酸钠溶液或糊状物。测定反应液的pH值以控制反应终点，pH=8时结束反应。对制得的苯甲酸钠直接真空干燥并粉碎，得到苯甲酸钠固体，分析苯甲酸钠质量指标，考察不同的NaOH浓度及不同的反应温度对皂化反应的影响。

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[ 海关编码 ]: 2916310090

[ 中文概述 ]:
2916310090 其他苯甲酸及其盐和酯. 增值税率:17.0% 退税率:9.0% 监管条件:AB(入境货物通关单,出境货物通关单) 最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 丙烯酸、丙烯酸盐或酯应报明包装

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验

[ Summary ]:
2916310090 other benzoic acid and its salts and esters。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:6.5%。general tariff:30.0%

Antibacterial activity of fluoride compounds and herbal toothpastes on Streptococcus mutans: an in vitro study.

Aust. Dent. J. 60 , 368-74, (2015)

Streptococcus mutans is an important bacterial species implicated in dental caries. This laboratory study compared the antimicrobial activity of a number of fluoride containing and herbal dentifrices ...

Role of type I & type II radicals in DNA damage and activation of Caspase 3 via mitochondrial pathway induced by photosensitized benzophenone

Toxicol. Lett. 235(2) , 84-95, (2015)

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Novel UV-spectrophotometric method for quantitative estimation of furazolidone using mixed hydrotropic agent.

Pak. J. Pharm. Sci. 26(1) , 159-62, (2013)

A novel, eco friendly, accurate, sensitive, economic and safe spectrophotometric method was developed by application of mixed hydrotropy using 2 M sodium acetate, 8 M urea, 2 M niacinamide and 2 M sod...

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公司名：南通润丰石油化工有限公司

区域：南通市崇川区

价格：
￥需询单/1kg ￥需询单/1ton

联系人：曹经理

产品详情：苯甲酸钠

公司名：上海吉至生化科技有限公司

区域：上海市奉贤区

价格：
￥68.0/500g

联系人：刘佳

产品详情：苯甲酸钠

公司名：上海脉铂医药科技有限公司

区域：上海市嘉定区

价格：
￥489.0/50mg ￥需询单/1g ￥需询单/1g ￥需询单/1g

联系人：李先生

产品详情：Sodium benzoate

公司名：上海阿拉丁生化科技股份有限公司

区域：上海市浦东新区

价格：
￥51.9/250g ￥66.9/500g ￥38.9/100g ￥51.9/250g

联系人：阿拉丁李高志

产品详情：苯甲酸钠

公司名：上海创赛科技有限公司

区域：上海市嘉定区

价格：
￥1277.0/25kg ￥70.0/500g ￥376.0/5kg ￥490.0/50mg

联系人：夏言

产品详情：[Perfemiker]苯甲酸钠,AR，99.5%

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苯甲酸钠供应商

苯甲酸钠的功效与制备

2022-05-05 11:14:42

苯甲酸钠，别名安息香酸钠，大多为白色颗粒或结晶性粉末，无臭味或者略带安息香气味，味微甜，其化学结构式为C7H5NaO2，是一种有机物，相对分子质量为144.103，闪点（燃点）较高，110度，因此在空气中颇为稳定，易溶于水，其水溶液的pH值为7.0-8.5，稍溶于乙醇，可溶于乙醇，更多的物化性质资...

苯甲酸钠

苯甲酸钠用途

苯甲酸钠名称

苯甲酸钠生物活性

苯甲酸钠物理化学性质