N,N′-二甲基硫脲

N,N′-二甲基硫脲用途

N,N'-Dimethylthiourea (DMTU) 是从黑蒜中分离出来的,是口服有效的羟基自由基 (•OH) 的清除剂,通过活化的中性粒细胞在体外阻止 •OH 的产生。N,N'-Dimethylthiourea 通过发挥抗氧化作用,包括 •OH 清除和抗炎作用,防止水浸限制应激 (WIRS) 诱导的大鼠胃粘膜损伤。

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N,N′-二甲基硫脲名称

[ CAS 号 ]:
534-13-4

[ 中文名 ]:
N,N′-二甲基硫脲

[ 英文名 ]:
N,N'-Dimethylthiourea

[中文别名 ]:

[英文别名 ]:

Thiourea, N,N'-dimethyl-
N,N'-DIMETHYLTHIOUREA
1,3-dimethyl-2-thiourea
N,N‘-Dimethylthiourea
1,3-Dimethylthiourea
MFCD00004923
N,N′-dimethylthiourea
EINECS 208-588-2

N,N′-二甲基硫脲生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 炎症/免疫

[体内研究]

N、 N’-二甲基硫脲(DMTU；1、2.5或5 mmol/kg；在WIRS发病前0.5小时口服)可降低胃粘膜病变的严重程度,减轻胃粘膜MPO、促炎细胞因子、LPO、NOx、非蛋白SH的水平变化,6周龄雄性Wistar大鼠在WIRS发病后3h发现维生素C和胃粘液,呈剂量依赖性[1]。

[参考文献]

[1]. Yoshiji Ohta, et al. Protective effect of N,N'-dimethylthiourea against stress-induced gastric mucosal lesions in rats. Fundam Clin Pharmacol. 2017 Jun;31(3):319-328.

[2]. Zhongyi Zhang, et al. Analysis of volatile compounds in fermented black garlic by GC-MS.

N,N′-二甲基硫脲物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
121.6±23.0 °C at 760 mmHg

[ 熔点 ]:
61-63 °C

[ 分子式 ]:
C₃H₈N₂S

[ 分子量 ]:
104.174

[ 闪点 ]:
27.3±22.6 °C

[ 精确质量 ]:
104.040817

[ PSA ]:
56.15000

[ LogP ]:
-0.35

[ 外观性状 ]:
灰白色结晶粉末

[ 蒸汽压 ]:
14.5±0.2 mmHg at 25°C

[ 折射率 ]:
1.516

[ 储存条件 ]:
存放于惰性气体之中;避免湿气 (吸湿)

N,N′-二甲基硫脲MSDS

详细MSDS(安全技术说明书)

N,N′-二甲基硫脲毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YT1520000

CHEMICAL NAME :: Urea, 1,3-dimethyl-2-thio-

CAS REGISTRY NUMBER :: 534-13-4

BEILSTEIN REFERENCE NO. :: 0605454

LAST UPDATED :: 199701

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C3-H8-N2-S

MOLECULAR WEIGHT :: 104.19

WISWESSER LINE NOTATION :: SUYM1&M1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 23,335,1981

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FRBMEH Free Radical Biology and Medicine. (Pergamon Press, c/o Elsevier Science, 660 White Plains Rd., Tarrytown, NY 10591) V.3- 1987- Volume(issue)/page/year: 20,421,1996 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 2 gm/kg

SEX/DURATION :: female 14 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - eye/ear Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :: TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 23,335,1981

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 2 gm/kg

SEX/DURATION :: female 14 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

REFERENCE :: TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 23,335,1981

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 225 mg/kg

SEX/DURATION :: female 6-20 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 17,399,1991

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 3 gm/kg

SEX/DURATION :: female 6-20 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Specific Developmental Abnormalities - urogenital system

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 17,399,1991

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 500 mg/kg

SEX/DURATION :: female 10 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - eye/ear

REFERENCE :: TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 23,335,1981 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1809 No. of Facilities: 26 (estimated) No. of Industries: 1 No. of Occupations: 10 No. of Employees: 1351 (estimated) No. of Female Employees: 52 (estimated)

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N,N′-二甲基硫脲安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301-H317

[ 警示性声明 ]:
P280-P301 + P310

[ 个人防护装备 ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T: Toxic;

[ 风险声明 (欧洲) ]:
R25;R43

[ 安全声明 (欧洲) ]:
S36/37-S45

[ 危险品运输编码 ]:
UN 2811 6.1/PG 3

[ WGK德国 ]:
3

[ RTECS号 ]:
YT1520000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

[ 海关编码 ]:
2930909090

N,N′-二甲基硫脲上下游产品

N,N′-二甲基硫脲上游产品

N,N′-二甲基硫脲下游产品

N,N′-二甲基硫脲海关

[ 海关编码 ]: 2930909090

[ 中文概述 ]:
2930909090. 其他有机硫化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%