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6-氮杂尿苷

6-氮杂尿苷用途

6-阿扎尿苷(6-Azuridine)是嘌呤核苷类似物。嘌呤核苷类似物具有广泛的抗肿瘤活性,靶向惰性淋巴系统恶性肿瘤。这一过程中的抗癌机制依赖于抑制DNA合成、诱导细胞凋亡等[1]。
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6-氮杂尿苷名称

[ CAS 号 ]:
54-25-1

[ 中文名 ]:
6-氮杂尿苷

[ 英文名 ]:
6-AZAURIDINE

[中文别名 ]:

[英文别名 ]:

6-氮杂尿苷生物活性

[ 描述 ]:

6-阿扎尿苷(6-Azuridine)是嘌呤核苷类似物。嘌呤核苷类似物具有广泛的抗肿瘤活性,靶向惰性淋巴系统恶性肿瘤。这一过程中的抗癌机制依赖于抑制DNA合成、诱导细胞凋亡等[1]。

[ 相关类别 ]:

信号通路 >> 细胞周期/DNA损伤 >> 核苷抗代谢药/类似物
研究领域 >> 其他

[参考文献]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

6-氮杂尿苷物理化学性质

[ 密度 ]:
2.1±0.1 g/cm3

[ 熔点 ]:
157-159 °C(lit.)

[ 分子式 ]:
C8H11N3O6

[ 分子量 ]:
245.19

[ 精确质量 ]:
245.064789

[ PSA ]:
137.67000

[ LogP ]:
-1.96

[ 外观性状 ]:
固体;White to Almost white powder to crystal

[ 折射率 ]:
1.795

[ 储存条件 ]:
2-8°C

6-氮杂尿苷MSDS

详细MSDS(安全技术说明书)

6-氮杂尿苷毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
XY8575000
CHEMICAL NAME :
as-Triazine-3,5(2H,4H)-dione, 2-beta-D-ribofuranosyl-
CAS REGISTRY NUMBER :
54-25-1
BEILSTEIN REFERENCE NO. :
0032281
LAST UPDATED :
199709
DATA ITEMS CITED :
26
MOLECULAR FORMULA :
C8-H11-N3-O6
MOLECULAR WEIGHT :
245.22
WISWESSER LINE NOTATION :
T6NNVMVJ B- BT5OTJ CQ DQ E1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
9400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
11250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
3400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
2400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird - quail
DOSE/DURATION :
>316 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
8 gm/kg/32D-I
TOXIC EFFECTS :
Gastrointestinal - hypermotility, diarrhea Blood - leukopenia Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
DOSE :
150 mg/kg
SEX/DURATION :
female 47 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - other effects to embryo
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
84 mg/kg
SEX/DURATION :
female 6-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous System
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
252 mg/kg
SEX/DURATION :
female 6-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetal death Reproductive - Specific Developmental Abnormalities - body wall
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
330 mg/kg
SEX/DURATION :
female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
330 mg/kg
SEX/DURATION :
female 11 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
DOSE :
900 mg/kg
SEX/DURATION :
female 7-9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Fertility - abortion
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
DOSE :
900 mg/kg
SEX/DURATION :
female 12-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intramuscular
DOSE :
10 gm/kg
SEX/DURATION :
female 14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Unreported
DOSE :
6250 mg/kg
SEX/DURATION :
female 3-27 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
TYPE OF TEST :
Specific locus test
TYPE OF TEST :
Sperm Morphology
TYPE OF TEST :
DNA inhibition
TYPE OF TEST :
Mutation test systems - not otherwise specified
TYPE OF TEST :
Cytogenetic analysis

MUTATION DATA

TEST SYSTEM :
Rodent - mouse
DOSE/DURATION :
5 gm/kg
REFERENCE :
CEFYAD Ceskoslovenska Fysiologie. (Academia, Vodickova 40, 112 29 Prague 1, Czechoslovakia) V.1- 1952- Volume(issue)/page/year: 21,278,1972 *** REVIEWS *** TOXICOLOGY REVIEW 32XPAD "Teratology," Berry, C.L., and D.E. Poswillo, eds., New York, Springer, 1975 Volume(issue)/page/year: -,49,1975
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6-氮杂尿苷安全信息

[ 符号 ]:

GHS07, GHS08

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H312-H332-H351

[ 警示性声明 ]:
P280

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R20/21/22

[ 安全声明 (欧洲) ]:
S22-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
XY8575000

6-氮杂尿苷合成路线

详细合成路线

6-氮杂尿苷上下游产品

6-氮杂尿苷上游产品

6-氮杂尿苷下游产品

6-氮杂尿苷制备

本品可由6-氯杂尿嘧啶(6-azauracil)通过大肠杆菌转化，也可用化学合成法制得。

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6-氮杂尿苷文献

The lipid moiety of brincidofovir is required for in vitro antiviral activity against Ebola virus.

Antiviral Res. 125 , 71-8, (2016)

Brincidofovir (BCV) is the 3-hexadecyloxy-1-propanol (HDP) lipid conjugate of the acyclic nucleoside phosphonate cidofovir (CDV). BCV has established broad-spectrum activity against double-stranded DN...

Cytotoxicity of diterpenes from Premna schimperi and Premna oligotricha.

Planta Med. 61(4) , 368-9, (1995)

The cytotoxicity of two diterpenes from Premna schimperi and Premna oligotricha (Verbenaceae) was studied using the MTT assay. Their cytotoxic activity against three human (HeLa, SK.N.SH, and ECV 304)...

New indications for 6-azauridine treatment in man. A review.

Eur. J. Clin. Pharmacol. 4(2) , 77-81, (1972)


更多文献

推荐生产厂家/供应商：

公司名：上海化源世纪贸易有限公司

区域：上海市普陀区

价格：

联系人：徐经理

产品详情：6-氮杂尿苷

公司名：上海阿拉丁生化科技股份有限公司

区域：上海市浦东新区

价格：
￥1788.0/5g ￥39.0/1mg ￥601.0/1g ￥需询单/1g

联系人：阿拉丁

产品详情：6-天蓝色

公司名：上海创赛科技有限公司

区域：上海市嘉定区

价格：
￥188.0/100mg ￥640.0/500mg ￥128.0/100mg ￥261.0/500mg

联系人：夏言

产品详情：[Perfemiker]6-氮杂尿苷,99%

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相关化合物

【6-氮杂尿苷】化源网提供6-氮杂尿苷CAS号54-25-1，6-氮杂尿苷MSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询6-氮杂尿苷上化源网，专业又轻松。>>电脑版：6-氮杂尿苷

标题：6-氮杂尿苷_MSDS_用途_密度_6-氮杂尿苷CAS号【54-25-1】_化源网 地址：https://m.chemsrc.com/mip/cas/54-25-1_246414.html