6-氮杂尿苷-2,3,5-三乙酸酯

6-氮杂尿苷-2,3,5-三乙酸酯用途

氮杂吡啶(2',3',5'-三-O-乙酰基-6-氮杂尿苷)是一种有效的乳清苷单磷酸脱羧酶(OMPD)抑制剂。氮唑宾是几种RNA病毒的抗病毒抑制剂,可抑制病毒基因组复制和基因转录。氮唑宾显示广谱抗病毒活性(EC50=3.80 纳米-1.73 μM抗甲型和乙型流感病毒；EC50=1.62μM对抗ZIKV Paraiba)。阿扎里滨是阿扎尿苷的三乙酸盐,有可能用于银屑病研究[1][2]。

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6-氮杂尿苷-2,3,5-三乙酸酯名称

[ CAS 号 ]:
2169-64-4

[ 中文名 ]:
6-氮杂尿苷-2,3,5-三乙酸酯

[ 英文名 ]:
6-AZAURIDINE 2',3',5'-TRIACETATE

[中文别名 ]:

[英文别名 ]:

EINECS 218-515-6
6-AZURD-TA
6-azauridine-2',3',5'-tri-O-acetate
triacetyl-6-azauridine
ta-azur
cb304
2',3',5'-TRI-O-ACETYL-6-AZAURIDINE
AZARIBINE
2',3',5'-triacetyl-6-azauridine

6-氮杂尿苷-2,3,5-三乙酸酯生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 抗感染 >> 流感病毒

研究领域 >> 感染

研究领域 >> 炎症/免疫

[体外研究]

氮唑宾(2',3',5'-三-O-乙酰基-6-氮杂尿苷；0-2μM；48小时) 对MDCK公司细胞具有细胞毒性 (MTT法：CC50=19.66μM)[1]阿扎里滨对禽流感增殖具有强效抑制作用 (MDCK细胞: EC50=0.29μM第549页细胞: EC50=0.55μM)[1]阿扎里滨在 MDCK公司细胞后处理期间显示出对季节性 H1N1型和 H3N2 IAV型和国际广播公司的抑制作用,第50周分别为 0.60μM、0.77μM、0.80μM[1]阿扎里滨在 16血红蛋白细胞的后处理过程中具有抗数控H1N1作用,第50周为 1.58μM[1]细胞毒性试验[1]细胞系：MDCK细胞浓度：0-2μM培养时间：48小时结果：对MDCK细胞具有细胞毒性(CC50=19.66 μM)。

[参考文献]

[1]. Jun-Gyu Park, et al. Identification and Characterization of Novel Compounds with Broad-Spectrum Antiviral Activity against Influenza A and B Viruses. J Virol. 2020 Mar 17;94(7):e02149-19.

[2]. Desarey Morales Vasquez, et al. Identification of Inhibitors of ZIKV Replication. Viruses. 2020 Sep 18;12(9):1041.

6-氮杂尿苷-2,3,5-三乙酸酯物理化学性质

[ 密度 ]:
1.6g/cm3

[ 熔点 ]:
99-101ºC(lit.)

[ 分子式 ]:
C₁₄H₁₇N₃O₉

[ 分子量 ]:
371.29900

[ 精确质量 ]:
371.09600

[ PSA ]:
155.88000

[ 折射率 ]:
1.621

6-氮杂尿苷-2,3,5-三乙酸酯MSDS

详细MSDS(安全技术说明书)

6-氮杂尿苷-2,3,5-三乙酸酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XY8577000

CHEMICAL NAME :: as-Triazine-3,5-(2H,4H)-dione, 2-(2',3',5'-triacetyl-beta-D-ribofuranosyl)-

CAS REGISTRY NUMBER :: 2169-64-4

LAST UPDATED :: 199612

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C14-H17-N3-O9

MOLECULAR WEIGHT :: 371.34

WISWESSER LINE NOTATION :: T6NNVMVJ B- CT5OTJ BOV1 DOV1 E1OV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human

DOSE/DURATION :: 5670 mg/kg/6W

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Blood - changes in cell count (unspecified)

REFERENCE :: AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1920- Volume(issue)/page/year: 108,272,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 12 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 17,511,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 7800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 17,511,1970 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 321 gm/kg/15W-I

TOXIC EFFECTS :: Gastrointestinal - hypermotility, diarrhea Blood - changes in erythrocyte (RBC) count Related to Chronic Data - death

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 17,511,1970

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - pig

DOSE/DURATION :: 30 gm/kg/14W-I

TOXIC EFFECTS :: Blood - changes in erythrocyte (RBC) count

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 17,511,1970

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6-氮杂尿苷-2,3,5-三乙酸酯安全信息

[ 安全声明 (欧洲) ]:
S22-S24/25

[ WGK德国 ]:
2

[ RTECS号 ]:
XY8577000