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吡啶-3-羧酸钠

吡啶-3-羧酸钠用途

【用途一】
烟酸的中间体。
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吡啶-3-羧酸钠名称

[ CAS 号 ]:
54-86-4

[ 中文名 ]:
烟酸钠

[ 英文名 ]:
sodium nicotinate

[中文别名 ]:

[英文别名 ]:

吡啶-3-羧酸钠物理化学性质

[ 密度 ]:
1.293g/cm3

[ 沸点 ]:
292.5ºC at 760mmHg

[ 熔点 ]:
236.6ºC

[ 分子式 ]:
C6H4NNaO2

[ 分子量 ]:
145.09100

[ 闪点 ]:
130.7ºC

[ 精确质量 ]:
145.01400

[ PSA ]:
53.02000

[ 储存条件 ]:
室温

吡啶-3-羧酸钠MSDS

详细MSDS(安全技术说明书)

吡啶-3-羧酸钠毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
QT2060000
CHEMICAL NAME :
Nicotinic acid, sodium salt
CAS REGISTRY NUMBER :
54-86-4
LAST UPDATED :
199709
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C6-H4-N-O2.Na
MOLECULAR WEIGHT :
145.10
WISWESSER LINE NOTATION :
T6NJ CVQ &-NA-

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 73,85,1941
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
3 gm/kg
TOXIC EFFECTS :
Behavioral - ataxia Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 65,95,1939
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2900 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 81,1748,1961 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
30 mg/kg
SEX/DURATION :
female 9-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Effects on Newborn - behavioral
REFERENCE :
BRBUDU Brain Research Bulletin. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1976- Volume(issue)/page/year: 29,363,1992
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吡啶-3-羧酸钠安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
36/37/38

[ 安全声明 (欧洲) ]:
S26-S37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
QT2060000

[ 海关编码 ]:
2933399090

吡啶-3-羧酸钠合成路线

详细合成路线

吡啶-3-羧酸钠上下游产品

吡啶-3-羧酸钠上游产品

吡啶-3-羧酸钠下游产品

吡啶-3-羧酸钠制备

【方法一】
可用甲基吡啶经氧化，或用喹啉经氧化（先生成吡啶二羧酸）、脱羧制得。
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吡啶-3-羧酸钠海关

[ 海关编码 ]: 2933399090

[ 中文概述 ]:
2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

吡啶-3-羧酸钠文献

Evidence for fatty acids mediating CL 316,243-induced reductions in blood glucose in mice.

Am. J. Physiol. Endocrinol. Metab. 307(7) , E563-70, (2014)

CL 316,243, a β3-adrenergic agonist, was developed as an antiobesity and diabetes drug and causes rapid decreases in blood glucose levels in mice. The mechanisms mediating this effect have not been fu...

The niacin required for optimum growth can be synthesized from L-tryptophan in growing mice lacking tryptophan-2,3-dioxygenase.

J. Nutr. 143(7) , 1046-51, (2013)

In mammals, nicotinamide (Nam) is biosynthesized from l-tryptophan (l-Trp). The enzymes involved in the initial step of the l-Trp→Nam pathway are l-Trp-2,3-dioxygenase (TDO) and indoleamine-2,3-dioxyg...

Conversion of nicotinic acid to trigonelline is catalyzed by N-methyltransferase belonged to motif B' methyltransferase family in Coffea arabica.

Biochem. Biophys. Res. Commun. 452(4) , 1060-6, (2014)

Trigonelline (N-methylnicotinate), a member of the pyridine alkaloids, accumulates in coffee beans along with caffeine. The biosynthetic pathway of trigonelline is not fully elucidated. While it is qu...


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【吡啶-3-羧酸钠】化源网提供吡啶-3-羧酸钠CAS号54-86-4，吡啶-3-羧酸钠MSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询吡啶-3-羧酸钠上化源网，专业又轻松。>>电脑版：吡啶-3-羧酸钠

标题：吡啶-3-羧酸钠_MSDS_用途_密度_CAS号【54-86-4】_化源网 地址：https://m.chemsrc.com/mip/cas/54-86-4_830573.html