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烟酸甲酯

烟酸甲酯用途

Methyl nicotinate是在酒精饮料中发现的盐酸甲酯,在非处方局部制剂中用作一种活性成分,用于治疗肌肉和关节疼痛。

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烟酸甲酯名称

[ CAS 号 ]:
93-60-7

[ 中文名 ]:
烟酸甲酯

[ 英文名 ]:
Methyl nicotinate

[中文别名 ]:

[英文别名 ]:

EINECS 202-261-8
NIACIN METHYL ESTER
Methyl nictinate
Methylpyridin-3-carboxylat
3-methoxycarbonylpyridine
nicotinic acid methyl ester
methylnicotinicacid
3-pyridinecarboxylic acid methyl ester
MFCD00006388
3-Pyridinecarboxylic acid, methyl ester

烟酸甲酯生物活性

[ 描述 ]:

Methyl nicotinate是在酒精饮料中发现的盐酸甲酯,在非处方局部制剂中用作一种活性成分,用于治疗肌肉和关节疼痛。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 炎症/免疫

[参考文献]

[1]. L. Johnston, et al. Muscle and joint pain: topical anti-inflammatories and analgesics: therapeutic. Professional Nursing Today, Volume 17, Issue 1, Jan 2013, p. 4-5.

烟酸甲酯物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
209.0±0.0 °C at 760 mmHg

[ 熔点 ]:
42-44 °C(lit.)

[ 分子式 ]:
C₇H₇NO₂

[ 分子量 ]:
137.136

[ 闪点 ]:
95.6±0.0 °C

[ 精确质量 ]:
137.047684

[ PSA ]:
39.19000

[ LogP ]:
0.88

[ 外观性状 ]:
白色至褐色晶体或结晶粉末

[ 蒸汽压 ]:
0.2±0.4 mmHg at 25°C

[ 折射率 ]:
1.511

[ 储存条件 ]:
室温

[ 水溶解性 ]:
NEGLIGIBLE

烟酸甲酯MSDS

烟酸甲酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QT1925000

CHEMICAL NAME :: Nicotinic acid, methyl ester

CAS REGISTRY NUMBER :: 93-60-7

BEILSTEIN REFERENCE NO. :: 0113951

LAST UPDATED :: 199712

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C7-H7-N-O2

MOLECULAR WEIGHT :: 137.15

WISWESSER LINE NOTATION :: T6NJ CVO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85IXA4 "Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948 Volume(issue)/page/year: -,428,1948

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CBCCT* "Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. (National Academy of Science Library, 2101 Constitution Ave., NW, Washington, DC 20418) Volume(issue)/page/year: 7,691,1955 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80460 No. of Facilities: 100 (estimated) No. of Industries: 3 No. of Occupations: 7 No. of Employees: 2857 (estimated)

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烟酸甲酯安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant

[ 风险声明 (欧洲) ]:
R36/38

[ 安全声明 (欧洲) ]:
S26-S36-S37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
QT1925000

[ 海关编码 ]:
2936290090

烟酸甲酯合成路线

烟酸甲酯上下游产品

烟酸甲酯上游产品

烟酸甲酯下游产品

烟酸甲酯制备

1. 烟草：BU，9；FC，40。通过向烟酸的热甲醇溶液中通氯化氢气体制备。

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烟酸甲酯海关

[ 海关编码 ]: 2933399090

[ 中文概述 ]:
2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

烟酸甲酯文献

cIEF for rapid pKa determination of small molecules: a proof of concept.

Eur. J. Pharm. Sci. 63 , 14-21, (2014)

A capillary isoelectric focusing (cIEF) method was developed for the determination of the ionization constants (pKa) of small molecules. Two approaches used to decrease the electroosmotic flow (EOF) w...

Parallel artificial membrane permeability assay: a new membrane for the fast prediction of passive human skin permeability.

J. Med. Chem. 49 , 3948-54, (2006)

This work was devoted to the search for new artificial membranes allowing a rapid evaluation of passive human skin permeation of compounds with a parallel artificial membrane permeability assay (PAMPA...

In silico and in vitro filters for the fast estimation of skin permeation and distribution of new chemical entities.

J. Med. Chem. 50 , 742-8, (2007)

The development of in silico and in vitro tools to estimate or predict the passive human skin permeation and distribution of new chemical entities, useful in dermal drug delivery, in absorption studie...

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烟酸甲酯

烟酸甲酯用途

烟酸甲酯名称

烟酸甲酯生物活性

烟酸甲酯物理化学性质

烟酸甲酯MSDS

详细MSDS(安全技术说明书)

烟酸甲酯毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

烟酸甲酯安全信息

烟酸甲酯合成路线

详细合成路线

烟酸甲酯上下游产品

烟酸甲酯上游产品

烟酸甲酯下游产品

烟酸甲酯制备

烟酸甲酯海关

烟酸甲酯文献

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