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3,3-二甲基丙烯酸

3,3-二甲基丙烯酸用途

【用途一】
用于涂料等
【用途二】
有机合成中间体。

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3,3-二甲基丙烯酸名称

[ CAS 号 ]:
541-47-9

[ 中文名 ]:
3,3-二甲基丙烯酸

[ 英文名 ]:
3,3-Dimethylacrylic acid

[中文别名 ]:

[英文别名 ]:

3-Methyl-2-butenoic acid
EINECS 208-782-7
β-Methylcrotonic acid
QV1UY1&1
3-Methylcrotonate
Senecic acid
2-Butenoic acid, 3-methyl-
But-2-enoic acid, 3-methyl-
Crotonic acid, 3-methyl-
Senecioic acid

3,3-二甲基丙烯酸物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
194.5±0.0 °C at 760 mmHg

[ 熔点 ]:
65-70 °C(lit.)

[ 分子式 ]:
C₅H₈O₂

[ 分子量 ]:
100.116

[ 闪点 ]:
95.9±9.6 °C

[ 精确质量 ]:
100.052429

[ PSA ]:
37.30000

[ LogP ]:
1.35

[ 外观性状 ]:
白色晶体

[ 蒸汽压 ]:
0.2±0.7 mmHg at 25°C

[ 折射率 ]:
1.451

[ 储存条件 ]:
-20°C

3,3-二甲基丙烯酸MSDS

3,3-二甲基丙烯酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GQ5425000

CHEMICAL NAME :: Crotonic acid, 3-methyl-

CAS REGISTRY NUMBER :: 541-47-9

BEILSTEIN REFERENCE NO. :: 1720305

LAST UPDATED :: 199701

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C5-H8-O2

MOLECULAR WEIGHT :: 100.13

WISWESSER LINE NOTATION :: QV1UY1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Open irritation test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) Volume(issue)/page/year: 8/23/1967

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,309,1986

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) Volume(issue)/page/year: 8/23/1967

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,309,1986 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3560 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 28,313,1974

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2580 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 29(4),52,1985

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >3200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 28,313,1974

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 3 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 29(4),52,1985 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 10 mg/m3 JAN 1993

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3,3-二甲基丙烯酸安全信息

[ 符号 ]:

GHS05, GHS07

[ 信号词 ]:
Danger

[ 危害声明 ]:
H315-H318-H335

[ 警示性声明 ]:
P261-P280-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant;

[ 风险声明 (欧洲) ]:
R37/38;R41

[ 安全声明 (欧洲) ]:
S26-S36/37/39

[ 危险品运输编码 ]:
3261

[ WGK德国 ]:
1

[ RTECS号 ]:
GQ5425000

[ 包装等级 ]:
III

[ 危险类别 ]:
8

[ 海关编码 ]:
2916190090

3,3-二甲基丙烯酸合成路线

3,3-二甲基丙烯酸上下游产品

3,3-二甲基丙烯酸上游产品

3,3-二甲基丙烯酸下游产品

3,3-二甲基丙烯酸制备

异丙叉丙酮和次氯酸钾水溶液在二氧六环中反应，反应放热使生成的氯仿回流。反应毕，加入亚硫酸氢钠与过量的次氯酸盐作用。用硫酸酸化、乙醚提取，从提取液减压蒸馏得到3-甲基-2-丁烯酸。收率49-53%。

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3,3-二甲基丙烯酸海关

[ 海关编码 ]: 2916190090

[ 中文概述 ]:
2916190090 其他不饱和无环一元羧酸（包括其酸酐、酰卤化物，过氧化物和过氧酸以及它们的衍生物）。监管条件:AB(入境货物通关单,出境货物通关单)。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 丙烯酸、丙烯酸盐或酯应报明包装

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验

[ Summary ]:
2916190090 unsaturated acyclic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:6.5%。general tariff:30.0%

3,3-二甲基丙烯酸文献

Chemically engineering ligand selectivity at the free fatty acid receptor 2 based on pharmacological variation between species orthologs.

FASEB J. 26 , 4951-65, (2012)

When it is difficult to develop selective ligands within a family of related G-protein-coupled receptors (GPCRs), chemically engineered receptors activated solely by synthetic ligands (RASSLs) are use...

Structure-activity relationships of trans-substituted-propenoic acid derivatives on the nicotinic acid receptor HCA2 (GPR109A).

Bioorg. Med. Chem. Lett. 21 , 2736-9, (2011)

Nicotinic acid (niacin) has been used for decades as an antidyslipidemic drug in man. Its main target is the hydroxy-carboxylic acid receptor HCA2 (GPR109A), a G protein-coupled receptor. Other acids ...

Tritium-labelled isovaleryl-RYYRIK-NH2 as potential antagonist probe for ORL1 nociceptin receptor.

Bioorg. Med. Chem. 22(21) , 5902-9, (2014)

IsoVa-RYYRIK-NH2 is a highly specific antagonist ligand of the opioid receptor-like 1 (ORL1) receptor, an endogenous ligand of which is 17-mer peptide nociceptin. ORL1 antagonists have potential for c...

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3,3-二甲基丙烯酸

3,3-二甲基丙烯酸用途

3,3-二甲基丙烯酸名称

3,3-二甲基丙烯酸物理化学性质

3,3-二甲基丙烯酸MSDS

详细MSDS(安全技术说明书)

3,3-二甲基丙烯酸毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

3,3-二甲基丙烯酸安全信息

3,3-二甲基丙烯酸合成路线

详细合成路线

3,3-二甲基丙烯酸上下游产品

3,3-二甲基丙烯酸上游产品

3,3-二甲基丙烯酸下游产品

3,3-二甲基丙烯酸制备

3,3-二甲基丙烯酸海关

3,3-二甲基丙烯酸文献

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