6-乙基疏基嘌呤

6-乙基疏基嘌呤名称

[ CAS 号 ]:
5417-84-5

[ 中文名 ]:
6-乙基疏基嘌呤

[ 英文名 ]:
9H-Purine,6-(ethylthio)-

[英文别名 ]:

6-Ethylmercaptopurine
QA 69
6-ETHYLTHIOPURINE
6-Ethyl MP

6-乙基疏基嘌呤物理化学性质

[ 密度 ]:
1.39g/cm3

[ 沸点 ]:
460.2ºC at 760mmHg

[ 分子式 ]:
C₇H₈N₄S

[ 分子量 ]:
180.23000

[ 闪点 ]:
232.1ºC

[ 精确质量 ]:
180.04700

[ PSA ]:
79.76000

[ LogP ]:
1.46490

[ 折射率 ]:
1.758

6-乙基疏基嘌呤MSDS

6-乙基疏基嘌呤毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UO8535000

CHEMICAL NAME :: Purine, 6-(ethylthio)-

CAS REGISTRY NUMBER :: 5417-84-5

LAST UPDATED :: 198502

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C7-H8-N4-S

MOLECULAR WEIGHT :: 180.25

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 164 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 71,618,1982

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6-乙基疏基嘌呤安全信息

[ 符号 ]:

GHS08

[ 信号词 ]:
Warning

[ 危害声明 ]:
H351

[ 警示性声明 ]:
P281

[ 个人防护装备 ]:
Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
40

[ 安全声明 (欧洲) ]:
22-36

[ 危险品运输编码 ]:
UN 2811 6.1/PG 3

[ RTECS号 ]:
UO8535000

[ 海关编码 ]:
2933990090

6-乙基疏基嘌呤合成路线

6-乙基疏基嘌呤上下游产品

6-乙基疏基嘌呤上游产品

6-乙基疏基嘌呤下游产品

6-乙基疏基嘌呤海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

6-乙基疏基嘌呤文献

Induction of the c-ski proto-oncogene by phorbol ester correlates with induction of megakaryocyte differentiation.

Oncogene 9(5) , 1407-16, (1994)

Overexpression of v-ski blocks the terminal differentiation of chicken erythroblasts, and in cooperation with v-sea causes transformation of these cells, indicating that c-ski may play a role in regul...

6-ethylmercaptopurine-mediated growth inhibition of HL-60 cells in vitro irrespective of purine salvage.

Cancer Chemother. Pharmacol. 25(3) , 189-94, (1989)

A variety of purine analogs inhibit the growth and induce the differentiation of human promyelocytic leukemia (HL-60) cells that lack the purine salvage enzyme hypoxanthine-guanine phosphoribosyltrans...

Differential effect of 6-ethylmercaptopurine on c-myc expression in wild-type and HGPRT-deficient HL-60 cells.

Cancer Chemother. Pharmacol. 27(3) , 171-7, (1990)

A variety of compounds inhibit the growth and induce differentiation of human promyelocytic leukemia (HL-60) cells. HL-60 subclones that lack the purine salvage enzyme hypoxanthine-guanine phosphoribo...

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