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乌发醇

乌发醇用途

Uvaol 是一种存在于橄榄和初榨橄榄油中的三萜类化合物,具有抗炎和抗氧化作用。Uvaol 可减轻卵清蛋白致敏小鼠的胸膜炎和嗜酸性粒细胞炎。

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乌发醇名称

[ CAS 号 ]:
545-46-0

[ 中文名 ]:
乌发醇

[ 英文名 ]:
Uvaol

[中文别名 ]:

熊果醇

[英文别名 ]:

urs-12-ene-3,28-diol
Urs-12-ene-3,28-diol, (3β)-
urs-12-ene-3beta,28-diol
12-URSEN-3BETA,28 DIOL
3B,28-DIHYDROXY-URSA-12-EN
(3β)-Urs-12-ene-3,28-diol
12-URSEN-3B,28-DIOL
Uvaol,Urs-12-ene-3,28-diol
Urs-12-ene-3β,28-diol
Urs-12-ene-3b,28-diol

乌发醇生物活性

[ 描述 ]:

Uvaol 是一种存在于橄榄和初榨橄榄油中的三萜类化合物,具有抗炎和抗氧化作用。Uvaol 可减轻卵清蛋白致敏小鼠的胸膜炎和嗜酸性粒细胞炎。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 炎症/免疫

[参考文献]

[1]. Agra LC, et al. Uvaol attenuates pleuritis and eosinophilic inflammation in ovalbumin-induced allergy in mice. Eur J Pharmacol. 2016 Jun 5;780:232-42.

乌发醇物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
523.7±50.0 °C at 760 mmHg

[ 熔点 ]:
223-225ºC(lit.)

[ 分子式 ]:
C₃₀H₅₀O₂

[ 分子量 ]:
442.717

[ 闪点 ]:
211.6±24.7 °C

[ 精确质量 ]:
442.381073

[ PSA ]:
40.46000

[ LogP ]:
9.13

[ 外观性状 ]:
粉末

[ 蒸汽压 ]:
0.0±3.1 mmHg at 25°C

[ 折射率 ]:
1.550

[ 储存条件 ]:
2-8℃，干燥，密闭

乌发醇安全信息

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
22-45

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

乌发醇合成路线

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乌发醇文献

Changes of the wax contents in mixtures of olive oils as determined by gas chromatography with a flame ionization detector.

J. AOAC Int. 95(6) , 1720-4, (2012)

Mixing of refined olive-pomace oil with virgin olive oil is a fraud that has been tried often. Normally, the tests that detected the fraud were determinations of wax esters, erythrodiol+uvaol, and sti...

Modulation of cytokine secretion by pentacyclic triterpenes from olive pomace oil in human mononuclear cells.

Cytokine 36(5-6) , 211-7, (2006)

Olive pomace oil, also known as "orujo" olive oil, is a blend of refined-pomace oil and virgin olive oil, fit for human consumption. Maslinic acid, oleanolic acid, erythrodiol, and uvaol are pentacycl...

Study of skin anti-ageing and anti-inflammatory effects of dihydroquercetin, natural triterpenoids, and their synthetic derivatives.

Bioorg. Khim. 38(3) , 374-81, (2012)

Accessible triterpenoids of ursane and lupane series, the flavonoid dihydroquercetin and their synthetic derivatives with polar substituentss were tested in vitro for inhibition of collagenase 1 (MMP-...

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乌发醇