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盐酸羟胺

盐酸羟胺用途

Hydroxyamine hydrochloride 是一种选择性单胺氧化酶 (MAO) 抑制剂,可用于抑制血小板聚集。Hydroxyamine hydrochloride 是有机合成的中间体。

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盐酸羟胺作用

用作医药和有机合成的原料

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盐酸羟胺名称

[ CAS 号 ]:
5470-11-1

[ 中文名 ]:
盐酸羟胺

[ 英文名 ]:
Hydroxyamine hydrochloride

[中文别名 ]:

[英文别名 ]:

EINECS 226-798-2
MFCD00051089
Hydroxylammonium chloride
Ammonium, hydroxy-, chloride (1:1)
hydroxylamine,hydrochloride

盐酸羟胺生物活性

[ 描述 ]:

Hydroxyamine hydrochloride 是一种选择性单胺氧化酶 (MAO) 抑制剂,可用于抑制血小板聚集。Hydroxyamine hydrochloride 是有机合成的中间体。

[ 相关类别 ]:

研究领域 >> 心血管疾病

信号通路 >> 神经信号通路 >> 单胺氧化酶

[体外研究]

盐酸羟胺(1mm)抑制MAO活性达99.8%[1]。

[参考文献]

[1]. Roh JH, et al. Purification, characterization, and crystallization of monoamine oxidase from Escherichia coli K-12. Biosci Biotechnol Biochem. 1994 Sep;58(9):1652-6.

盐酸羟胺物理化学性质

[ 密度 ]:
1.67 g/mL at 25 °C(lit.)

[ 沸点 ]:
56.5ºC at 760mmHg

[ 熔点 ]:
155-157 °C (dec.)(lit.)

[ 分子式 ]:
ClH₄NO

[ 分子量 ]:
69.491

[ 精确质量 ]:
68.998138

[ PSA ]:
46.25000

[ LogP ]:
0.83660

[ 外观性状 ]:
无色或灰白色结晶固体

[ 储存条件 ]:
Store at RT.

[ 稳定性 ]:
Substances to be avoided include strong oxidizing agents. Heating above 115 C may cause explosion; do not store above 65C. Moisture and air sensitive.

[ 水溶解性 ]:
560 g/L (20 ºC)

盐酸羟胺MSDS

盐酸羟胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NC3675000

CHEMICAL NAME :: Hydroxylamine, hydrochloride

CAS REGISTRY NUMBER :: 5470-11-1

LAST UPDATED :: 199710

DATA ITEMS CITED :: 46

MOLECULAR FORMULA :: Cl-H.H3-N-O

MOLECULAR WEIGHT :: 69.50

WISWESSER LINE NOTATION :: ZQ &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 141 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 408 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 10 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 125 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 70 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 49500 mg/kg/25W-I

TOXIC EFFECTS :: Endocrine - changes in spleen weight Endocrine - changes in thyroid weight

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2478 mg/kg/6D-C

TOXIC EFFECTS :: Behavioral - food intake (animal) Blood - changes in leukocyte (WBC) count Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: Specific locus test

TYPE OF TEST :: Cytogenetic analysis

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Mammal - species unspecified Lymphocyte

DOSE/DURATION :: 25 mg/L

REFERENCE :: IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- Volume(issue)/page/year: 20,726,1982 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 38950 No. of Facilities: 1202 (estimated) No. of Industries: 18 No. of Occupations: 11 No. of Employees: 6578 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 38950 No. of Facilities: 1258 (estimated) No. of Industries: 20 No. of Occupations: 26 No. of Employees: 15258 (estimated) No. of Female Employees: 4469 (estimated)

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盐酸羟胺安全信息

[ 符号 ]:

GHS05, GHS07, GHS08, GHS09

[ 信号词 ]:
Warning

[ 危害声明 ]:
H290-H302 + H312-H315-H317-H319-H351-H373-H410

[ 警示性声明 ]:
P273-P280-P305 + P351 + P338-P501

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R22;R36/38;R43;R48/22;R50

[ 安全声明 (欧洲) ]:
S22-S24-S37-S61

[ 危险品运输编码 ]:
UN 2923 8/PG 2

[ WGK德国 ]:
3

[ RTECS号 ]:
NC3675000

[ 包装等级 ]:
III

[ 危险类别 ]:
8

[ 海关编码 ]:
2935009090

盐酸羟胺合成路线

盐酸羟胺上下游产品

盐酸羟胺上游产品

盐酸羟胺下游产品

盐酸羟胺制备

1.亚硝酸钠合成法（肟化法）将水加入反应釜，搅拌下加入亚硝酸钠，分次加入焦亚硫酸钠，然后用硫酸酸化。将酸化后的物料送入水解釜，加入丙酮，再用液碱中和，将中和液蒸馏，得丙酮肟。将丙酮肟和盐酸加入成盐釜中反应，生成盐酸羟胺和丙酮。丙酮回收使用；盐酸羟胺经浓缩、冷却结晶、离心分离、干燥，即得成品。其反应式如下：原料消耗定额：亚硝酸钠（95%）1970kg/t、焦亚硫酸钠（以SO2计64%）5418kg/t、丙酮（98%）1175kg/t。2.硝基甲烷法硝基甲烷与盐酸、水作用以制得盐酸羟胺。按HGB3044-76，盐酸羟胺产品为白色结晶，二级品含量≥98.5，三级品含量≥97%。原料消耗定额：硝基甲烷1200kg/t、盐酸（30%）1500kg/t。 2. 在亚硝酸钠的水溶液中，分次加入一定量的焦亚硫酸钠，然后用硫酸酸化。酸化后的料液送入水解釜，加一定量的丙酮，然后用碱中和。中和液经蒸馏得到丙酮肟。丙酮肟和盐酸反应生成盐酸羟胺和丙酮。盐酸羟胺达到一定浓度后，进行冷却结晶、离心分离、干燥即可。或者由硝基甲烷与盐酸、水作用以制得盐酸羟胺。 3. 亚硝酸钠加水溶解，降温至0℃，加入亚硫酸氢钠和35%～40%的稀硫酸使溶液ph＝2，加丙酮温度升至35℃时，停止搅拌，温升至70℃保温3h，降温至30℃，加氢氧化钠溶液至ph值7～8。加热将丙酮肟蒸出，加入盐酸，维持温度55～60℃，保温12h，然后进行浓缩。稍冷后脱色，过滤，再浓缩、冷却、结晶，则得成品。过程反应式：精制可采取乙醇浸泡或水重结晶。

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盐酸羟胺海关

[ 海关编码 ]: 2935009090

[ 中文概述 ]:
2935009090 其他磺（酰）胺. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:35.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

盐酸羟胺文献

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SIRT6 is a histone deacetylase that has been proposed as a potential therapeutic target for metabolic disorders and the prevention of age-associated diseases. Thus the identification of compounds that...

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Arch. Toxicol. 89(3) , 357-69, (2015)

Superparamagnetic iron oxide nanoparticles (IONPs) have been widely applied in numerous biomedical fields. The evaluation of the toxicity of IONPs to the environment and human beings is indispensable ...

Novel oral phosphate binder with nanocrystalline maghemite-phosphate binding capacity and pH effect.

Int. J. Pharm. 482(1-2) , 21-6, (2015)

Hyperphosphatemia is one of the main risk factors contributing to morbidity and mortality in patients with end stage renal disease. The demand for a new phosphate binder is continuously increasing sin...

更多文献

盐酸羟胺

盐酸羟胺用途

盐酸羟胺作用

盐酸羟胺名称

盐酸羟胺生物活性

盐酸羟胺物理化学性质

盐酸羟胺MSDS

详细MSDS(安全技术说明书)

盐酸羟胺毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

盐酸羟胺安全信息

盐酸羟胺合成路线

详细合成路线

盐酸羟胺上下游产品

盐酸羟胺上游产品

盐酸羟胺下游产品

盐酸羟胺制备

盐酸羟胺海关

盐酸羟胺文献

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