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15-Hydroxyeicosatetraenoic acid

15-Hydroxyeicosatetraenoic acid用途

15(S)-HETE是尿中存在的内源性代谢产物,可用于Zellweger综合征的研究[1][2]。

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15-Hydroxyeicosatetraenoic acid名称

[ CAS 号 ]:
54845-95-3

[ 英文名 ]:
15-Hydroxyeicosatetraenoic acid

[英文别名 ]:

15(S)-HETE
icomucret
15-HETE
15-Hydroxyeicosatetraenoic acid

15-Hydroxyeicosatetraenoic acid生物活性

[ 描述 ]:

15(S)-HETE是尿中存在的内源性代谢产物,可用于Zellweger综合征的研究[1][2]。

[ 相关类别 ]:

研究领域 >> 炎症/免疫

[体外研究]

内源性代谢产物被定义为《京都基因和基因组百科全书》注释为我们基因组中约1900种代谢酶的底物或产物。在文献正文中很清楚,许多这些代谢产物都具有毒性[1]。

[参考文献]

[1]. Lee N, et al. Endogenous toxic metabolites and implications in cancer therapy. Oncogene. 2020 Aug;39(35):5709-5720.

[2]. Mayatepek E, et al. 12- and 15-hydroxyeicosatetraenoic acid are excreted in the urine of peroxisome-deficient patients: evidence for peroxisomal metabolism in vivo. Pediatr Res. 1996 Jan;39(1):146-9.

15-Hydroxyeicosatetraenoic acid物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
487.7±45.0 °C at 760 mmHg

[ 分子式 ]:
C₂₀H₃₂O₃

[ 分子量 ]:
320.466

[ 闪点 ]:
262.8±25.2 °C

[ 精确质量 ]:
320.235138

[ PSA ]:
57.53000

[ LogP ]:
5.22

[ 蒸汽压 ]:
0.0±2.8 mmHg at 25°C

[ 折射率 ]:
1.514

[ 储存条件 ]:
-20°C，密闭，干燥

15-Hydroxyeicosatetraenoic acidMSDS

15-Hydroxyeicosatetraenoic acid安全信息

[ 符号 ]:

GHS02, GHS07

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H315-H319-H335

[ 警示性声明 ]:
P210-P261-P305 + P351 + P338

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
F: Flammable;Xi: Irritant;

[ 风险声明 (欧洲) ]:
R11

[ 安全声明 (欧洲) ]:
7-16-26-36

[ 危险品运输编码 ]:
UN 1170 3

[ 海关编码 ]:
2918199090

15-Hydroxyeicosatetraenoic acid合成路线

15-Hydroxyeicosatetraenoic acid上下游产品

15-Hydroxyeicosatetraenoic acid上游产品

15-Hydroxyeicosatetraenoic acid下游产品

15-Hydroxyeicosatetraenoic acid海关

[ 海关编码 ]: 2918199090

[ 中文概述 ]:
HS: 2918199090. 其他含醇基但不含其他含氧基羧酸（包括其酸酐、酰卤化物、过氧化物和过氧酸及该税号的衍生物）. 增值税率:17.0%. 退税率:9.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2918199090 other carboxylic acids with alcohol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

15-Hydroxyeicosatetraenoic acid文献

HMDB: a knowledgebase for the human metabolome.

Nucleic Acids Res. 37(Database issue) , D603-10, (2009)

The Human Metabolome Database (HMDB, http://www.hmdb.ca) is a richly annotated resource that is designed to address the broad needs of biochemists, clinical chemists, physicians, medical geneticists, ...

The human serum metabolome.

PLoS ONE 6(2) , e16957, (2011)

Continuing improvements in analytical technology along with an increased interest in performing comprehensive, quantitative metabolic profiling, is leading to increased interest pressures within the m...

Lack of association of ALOX12 and ALOX15B polymorphisms with psoriasis despite altered urinary excretion of 12(S)-hydroxyeicosatetraenoic acid.

Br. J. Dermatol. 172(2) , 337-44, (2015)

Pro- and anti-inflammatory metabolites of arachidonic acid - eicosanoids - participate in skin homeostasis, affecting the growth and differentiation of keratinocytes. Alterations of 12-lipoxygenase (L...

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