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莽草素

莽草素用途

(Rac)-紫草素(紫草素)具有抗肿瘤活性(Rac)-紫草素(紫草素)通过诱导坏死性死亡来规避癌症耐药性[1][2]。

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莽草素名称

[ CAS 号 ]:
54952-43-1

[ 中文名 ]:
莽草素

[ 英文名 ]:
Shikonin

[中文别名 ]:

[英文别名 ]:

Arnebin-4
Alkannin
(±)-Alkannin
(+)-Alkannin
Shikonin

莽草素生物活性

[ 描述 ]:

(Rac)-紫草素(紫草素)具有抗肿瘤活性(Rac)-紫草素(紫草素)通过诱导坏死性死亡来规避癌症耐药性[1][2]。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 其他 >> 其他

[体外研究]

紫草素对药物敏感癌细胞系(MCF-7和HEK293)及其过度表达P-糖蛋白、Bcl-2或Bcl-xL的耐药细胞系显示出类似的效力,这是大多数临床癌症耐药的原因[2]。

[参考文献]

[1]. U Sankawa, Antitumor activity of shikonin and its derivatives. Chem Pharm Bull (Tokyo). 1977 Sep;25(9):2392-5.

[2]. Weidong Han, et al. Shikonin circumvents cancer drug resistance by induction of a necroptotic death. Mol Cancer Ther. 2007 May;6(5):1641-9.

莽草素物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
567.4±50.0 °C at 760 mmHg

[ 熔点 ]:
149 °C

[ 分子式 ]:
C₁₆H₁₆O₅

[ 分子量 ]:
288.295

[ 闪点 ]:
311.0±26.6 °C

[ 精确质量 ]:
288.099762

[ PSA ]:
94.83000

[ LogP ]:
4.35

[ 外观性状 ]:
固体;Orange to Brown powder to crystal

[ 蒸汽压 ]:
0.0±1.6 mmHg at 25°C

[ 折射率 ]:
1.642

[ 储存条件 ]:
0-10°C;避免加热

莽草素MSDS

详细MSDS(安全技术说明书)

莽草素安全信息

[ 符号 ]:

GHS07, GHS09

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H400

[ 警示性声明 ]:
P273

[ 危害码 (欧洲) ]:
Xn

[ 危险品运输编码 ]:
UN 3077 9 / PGIII

莽草素文献

Inhibitory effect of Shikonin on Candida albicans growth.

Biol. Pharm. Bull. 35(11) , 1956-63, (2012)

Our study showed that Shikonin (SK) could provide an action against almost all Candida albicans isolates tested. More importantly, to some Fluconazole (FCZ)-resistant Candida albicans, the action of S...

Screening for novel quorum-sensing inhibitors to interfere with the formation of Pseudomonas aeruginosa biofilm.

J. Med. Microbiol. 60(Pt 12) , 1827-34, (2011)

The objective of this study was to screen for novel quorum-sensing inhibitors (QSIs) from traditional Chinese medicines (TCMs) that inhibit bacterial biofilm formation. Six of 46 active components fou...

Optimization of shikonin homogenate extraction from Arnebia euchroma using response surface methodology.

Molecules 18(1) , 466-81, (2013)

An efficient homogenate extraction technique was employed for extracting shikonin from Arnebia euchroma. The homogenate extraction procedure was optimized and compared with other conventional extracti...

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莽草素