DL-去甲肾上腺素 盐酸盐

DL-Norepinephrine hydrochloride 是模拟内源性去甲肾上腺素的拟交感神经作用的合成苯乙胺。DL-Norepinephrine hydrochloride 是一种靶向 α1 adrenoceptor 和 β1 adrenoceptor 的神经递质,可降低心内膜下氧分压。

[ 描述 ]:

[ 相关类别 ]:

[ 靶点 ]

[参考文献]

[ 密度 ]:
1.397g/cm3

[ 沸点 ]:
442.6ºC at 760mmHg

[ 熔点 ]:
140-144ºC (dec.)

[ 分子式 ]:
C₈H₁₂ClNO₃

[ 分子量 ]:
205.639

[ 闪点 ]:
221.5ºC

[ 精确质量 ]:
205.050568

[ PSA ]:
86.71000

[ LogP ]:
1.59220

[ 外观性状 ]:
crystalline | off-white to tan

[ 储存条件 ]:
2-8°C

详细MSDS(安全技术说明书)

CHEMICAL IDENTIFICATION

RTECS NUMBER :

DN6650000

CHEMICAL NAME :

Benzyl alcohol, alpha-(aminomethyl)-3,4-dihydroxy-, hydrochloride-, (+-)-

CAS REGISTRY NUMBER :

55-27-6

LAST UPDATED :

199206

DATA ITEMS CITED :

5

MOLECULAR FORMULA :

C8-H11-N-O3.Cl-H

MOLECULAR WEIGHT :

205.66

WISWESSER LINE NOTATION :

Z1YQR CQ DQ &GH -R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Subcutaneous

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

2 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 71,62,1941

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

15600 ug/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 92,369,1948

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

5 mg/kg

TOXIC EFFECTS :

Behavioral - convulsions or effect on seizure threshold Vascular - regional or general arteriolar constriction Lungs, Thorax, or Respiration - acute pulmonary edema

REFERENCE :

JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 92,108,1948 ** REPRODUCTIVE DATA **

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Subcutaneous

DOSE :

13 mg/kg

SEX/DURATION :

female 7-19 day(s) after conception

TOXIC EFFECTS :

Reproductive - Effects on Newborn - behavioral

REFERENCE :

NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 85,79,1985

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Subcutaneous

DOSE :

3200 ng/kg

SEX/DURATION :

female 16 day(s) after conception

TOXIC EFFECTS :

Reproductive - Effects on Embryo or Fetus - fetal death

REFERENCE :

PRGLBA Prostaglandins. (Geron-X, Inc., P.O. Box 1108, Los Altos, CA 94022) V.1- 1972- Volume(issue)/page/year: 2,295,1972

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301

[ 警示性声明 ]:
P301 + P310

[ 个人防护装备 ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T

[ 风险声明 (欧洲) ]:
R25

[ 安全声明 (欧洲) ]:
36/37/39-45

[ 危险品运输编码 ]:
UN 2811

[ WGK德国 ]:
3

[ RTECS号 ]:
DN6650000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

[ 海关编码 ]:
2922509090

详细合成路线

[ 海关编码 ]: 2922509090

[ 中文概述 ]:
2922509090. 其他氨基醇酚、氨基酸酚及其他含氧基氨基化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件：AB. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验

[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Sympathetic activity induced by naloxone-precipitated morphine withdrawal is blocked in genetically engineered mice lacking functional CRF1 receptor.

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公司名：上海化源世纪贸易有限公司

区域：上海市普陀区

价格：

联系人：徐经理

产品详情：DL-去甲肾上腺素盐酸盐

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公司名：上海吉至生化科技有限公司

区域：上海市奉贤区

价格：
￥718.0/1g ￥2558.0/5g ￥8068.0/25g

联系人：刘佳

产品详情：DL-去甲肾上腺素 盐酸盐

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公司名：上海阿拉丁生化科技股份有限公司

区域：上海市浦东新区

价格：
￥122.9/200mg ￥119.9/1ml ￥471.9/1g ￥1701.9/5g

联系人：阿拉丁

产品详情：DL-去甲肾上腺素 盐酸盐

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公司名：上海创赛科技有限公司

区域：上海市嘉定区

价格：
￥128.0/200mg ￥502.0/1g ￥1809.0/5g ￥5543.0/25g

联系人：夏言

产品详情：[Perfemiker]DL-去甲肾上腺素 盐酸盐,97%

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公司名：武汉鼎信通药业有限公司

区域：武汉市江夏区

价格：
￥需询单/1kg ￥需询单/10kg ￥需询单/50kg ￥需询单/500kg

联系人：董浩

产品详情：盐酸去甲肾上腺素

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