地高辛杂质I
地高辛杂质I用途
生化研究。强心药。
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地高辛杂质I名称
[ CAS 号 ]:
5511-98-8
[ 中文名 ]:
α-乙酰基地高辛
[ 英文名 ]:
α-Acetyl Digoxin
[中文别名 ]:
[英文别名 ]:
- digoxigenin+zuckerkettewiebieacetyl-digitoxina
- 3'''-acetyldigoxin
- Alpha-Acetyl Digoxin
- desglucolanatosidec
- digorida
- EINECS 226-855-1
地高辛杂质I物理化学性质
[ 密度 ]:
1.35g/cm3
[ 沸点 ]:
935.6ºC at 760mmHg
[ 熔点 ]:
199-201ºC
[ 分子式 ]:
C43H66O15
[ 分子量 ]:
822.97500
[ 闪点 ]:
275.4ºC
[ 精确质量 ]:
822.44000
[ PSA ]:
209.13000
[ LogP ]:
2.78890
[ 折射率 ]:
1.591
[ 储存条件 ]:
库房通风低温干燥
地高辛杂质I毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- IH6300000
- CHEMICAL NAME :
- Digoxin, acetate, alpha-
- CAS REGISTRY NUMBER :
- 5511-98-8
- LAST UPDATED :
- 199512
- DATA ITEMS CITED :
- 7
- MOLECULAR FORMULA :
- C43-H66-O15
- MOLECULAR WEIGHT :
- 823.09
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - cat
- DOSE/DURATION :
- 200 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 159,1,1966
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - cat
- DOSE/DURATION :
- 230 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 22,1854,1972
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intraduodenal
- SPECIES OBSERVED :
- Mammal - cat
- DOSE/DURATION :
- 494 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 20,1765,1970
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 3300 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 159,1,1966
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 1880 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 70,39,1974 *** REVIEWS *** TOXICOLOGY REVIEW 85ELDJ "Die Herzwirksamen Glykoside," Baumgarten, G., and W. Forster, Leipzig, Ger. Dem. Rep., VEB Georg Thieme, 1963 Volume(issue)/page/year: -,187,1963 TOXICOLOGY REVIEW 85ELDJ "Die Herzwirksamen Glykoside," Baumgarten, G., and W. Forster, Leipzig, Ger. Dem. Rep., VEB Georg Thieme, 1963 Volume(issue)/page/year: -,54,1963
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地高辛杂质I安全信息
[ 危险品运输编码 ]:
UN 3249
[ 包装等级 ]:
II
[ 危险类别 ]:
6.1(a)
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