乙酰氯

【用途一】
用于有机合成、染料及医药等工业
【用途二】
用作分析试剂，也用于乙酰基衍生物和染料的制备
【用途三】
是乙酰化剂，用作农药和医药的原料，还是制造水处理剂亚乙基二磷酸的中间体
【用途四】
为农药和医药的原料，还是制造水处理剂亚乙基二磷酸的中间体，也用于制造新型电镀络合剂。乙酰氯是重要的乙酰化试剂，酰化能力比乙酐强，广泛用于有机合成，染料。也是羧酸发生氯化反应的催化剂，还可用于羟基和氨基的定量分析。
【用途五】
测定胆固醇及有机液体中的水分、测定羟基四乙基铅等，鉴定亚硝基。用作乙酰化试剂。用于制药的染料合成。

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
46.0±3.0 °C at 760 mmHg

[ 熔点 ]:
-112 °C

[ 分子式 ]:
C₂H₃ClO

[ 分子量 ]:
78.498

[ 闪点 ]:
4.4±0.0 °C

[ 精确质量 ]:
77.987244

[ PSA ]:
17.07000

[ LogP ]:
0.46

[ 外观性状 ]:
无色至淡黄色液体带有一种辛辣

[ 蒸汽密度 ]:
2.7 (vs air)

[ 蒸汽压 ]:
341.6±0.1 mmHg at 25°C

[ 折射率 ]:
1.379

[ 储存条件 ]:
库房通风低温干燥,与氧化剂、酸类分开存放

[ 水溶解性 ]:
混溶：乙醚,苯,氯仿；可溶于：丙酮

详细MSDS(安全技术说明书)

CHEMICAL IDENTIFICATION

RTECS NUMBER :

AO6390000

CHEMICAL NAME :

Acetyl chloride

CAS REGISTRY NUMBER :

75-36-5

BEILSTEIN REFERENCE NO. :

0605303

LAST UPDATED :

199701

DATA ITEMS CITED :

6

MOLECULAR FORMULA :

C2-H3-Cl-O

MOLECULAR WEIGHT :

78.50

WISWESSER LINE NOTATION :

GV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Human

DOSE/DURATION :

2 ppm/1M

TOXIC EFFECTS :

Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Lungs, Thorax, or Respiration - other changes

REFERENCE :

TGNCDL "Handbook of Organic Industrial Solvents," 2nd ed., Chicago, National Assoc. of Mutual Casualty Companies, 1961 Volume(issue)/page/year: 2,28,1961

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

910 mg/kg

TOXIC EFFECTS :

Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - excitement Lungs, Thorax, or Respiration - other changes

REFERENCE :

GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 32(3),48,1988 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81687 No. of Facilities: 96 (estimated) No. of Industries: 4 No. of Occupations: 7 No. of Employees: 931 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81687 No. of Facilities: 40 (estimated) No. of Industries: 3 No. of Occupations: 5 No. of Employees: 2534 (estimated) No. of Female Employees: 575 (estimated)

[ 符号 ]:

GHS02, GHS05, GHS07

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H302-H314

[ 补充危害声明 ]:
Reacts violently with water.

[ 警示性声明 ]:
P210-P280-P305 + P351 + P338-P310

[ 个人防护装备 ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US)

[ 危害码 (欧洲) ]:
C:Corrosive

[ 风险声明 (欧洲) ]:
R11;R14;R34

[ 安全声明 (欧洲) ]:
S9-S16-S26-S45-S1/2

[ 危险品运输编码 ]:
UN 1717 3/PG 2

[ WGK德国 ]:
1

[ RTECS号 ]:
AO6390000

[ 包装等级 ]:
II

[ 危险类别 ]:
3

[ 海关编码 ]:
2915900090

详细合成路线

乙酰氯上游产品

乙酰氯下游产品

工业上，乙酰氯可由乙烯配氯化氢反应，或由乙酸钠，二氧化硫与氯反应制得。实验室可由乙酸，乙酸钠或乙酐与各种氯化剂反应制得。例如乙酐与氯磺酸(或氯化氢,四氯化碳,光气)反应得到。也可用冰醋酸与苯甲酰氯(或四氯化硅，三氯化磷，氯化亚硫酸，五氯化磷，)反应得到。操作实例1：配料比(摩尔比)为冰醋酸：三氯化磷=3：1.2。将冰醋酸加入反应器，缓慢搅拌，于室温下在10-15min内滴加三氯化磷。加热升温，保持40-50℃反应0.5h，反应产物静置，分离即得乙酰氯粗品，纯收率70%左右。操作实例2 在3L三口烧瓶中，放入360g(6mol)冰醋酸和552g甲苯，加热至50℃于30min内滴加510g(3mol)四氯化硅，并在50℃保温至氯化氢气体不再急剧逸出为止。再进行分馏，蒸至柱顶温度80-85℃为止得粗品。精品再蒸馏，取50-65馏分，得乙酰氯400g，产率85%。原料消耗定额：冰醋酸850kg/t、三氯化磷1950kg/t。

[ 海关编码 ]: 2915900090

[ 中文概述 ]:
2915900090. 其他饱和无环一元羧酸及其酸酐（酰卤、过氧）化物、过氧酸及其卤化、硝化、磺化、亚硝化衍生物. 增值税率:17.0%. 退税率:9.0%. 监管条件:AB(入境货物通关单,出境货物通关单). 最惠国关税:5.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验

[ Summary ]:
2915900090 other saturated acyclic monocarboxylic acids and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:5.5% General tariff:30.0%

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Limited effect of recombinant human mannose-binding lectin on the infection of novel influenza A (H7N9) virus in vitro.

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公司名：上海化源世纪贸易有限公司

区域：上海市普陀区

价格：

联系人：徐经理

产品详情：乙酰氯

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公司名：上海吉至生化科技有限公司

区域：上海市奉贤区

价格：
￥118.0/500ml

联系人：刘佳

产品详情：乙酰氯

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公司名：上海阿拉丁生化科技股份有限公司

区域：上海市浦东新区

价格：
￥需询单/1mg ￥需询单/1mg ￥需询单/1mg ￥需询单/1mg

联系人：阿拉丁

产品详情：乙酰氯

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公司名：济南世纪通达化工有限公司

区域：济南市天桥区

价格：
￥8500.0/1ton ￥16800.0/2ton

联系人：王经理

产品详情：乙酰氯

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公司名：山东金悦源新材料有限公司

区域：济南市天桥区

价格：
￥1200.0/200kg ￥6000.0/1ton

联系人：王思兵

产品详情：乙酰氯

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