Avarol

Avarol用途

Avarol induces apoptosis in pancreatic ductal adenocarcinoma cells by activating PERK-eIF2α-CHOP signaling. Avarl also acts as a competitive AChE inhibitor which are non-hepatotoxic and neuroprotective agents for Alzheimer's disease.

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Avarol名称

[ CAS 号 ]:
55303-98-5

[ 英文名 ]:
Avarol

[英文别名 ]:

Avarol
Avrol

Avarol物理化学性质

[ 密度 ]:
1.055g/cm3

[ 沸点 ]:
449.5ºC at 760 mmHg

[ 分子式 ]:
C₂₁H₃₀O₂

[ 分子量 ]:
314.46200

[ 闪点 ]:
200ºC

[ 精确质量 ]:
314.22500

[ PSA ]:
40.46000

[ LogP ]:
5.43910

[ 折射率 ]:
1.552

Avarol毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CZ9026700

CHEMICAL NAME :: 1,4-Benzenediol, 2-((1,2,3,4,4a,7,8,8a-octahydro-1,2,4a,5-tetramethyl- 1-naphthalenyl) methyl)-, (1R-(1-alpha,2-beta,4a-beta,8a-alpha))-

CAS REGISTRY NUMBER :: 55303-98-5

LAST UPDATED :: 199406

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C21-H30-O2

MOLECULAR WEIGHT :: 314.51

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 269 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Rodent - mouse Cells - not otherwise specified

DOSE/DURATION :: 3800 nmol/L

REFERENCE :: EJCODS European Journal of Cancer and Clinical Oncology. (Pergamon Press, c/o Elsevier Science, 660 White Plains Rd., Tarrytown, NY 10591) V.17(7)- 25, 1981-89. For publisher information, see EJCAEL Volume(issue)/page/year: 22,473,1986

Avarol

Avarol用途

Avarol名称

Avarol物理化学性质

Avarol毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

Avarol合成路线

详细合成路线

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