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除草素A

除草素A用途

除草剂A是一种腺苷衍生的核苷抗生素,也是一种针对双子叶植物的除草剂。除草剂素A可从斯氏链霉菌M40[1][2]中分离得到。

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除草素A名称

[ CAS 号 ]:
55353-31-6

[ 中文名 ]:
除草素A

[ 英文名 ]:
Herbicidin A

除草素A生物活性

[ 描述 ]:

除草剂A是一种腺苷衍生的核苷抗生素,也是一种针对双子叶植物的除草剂。除草剂素A可从斯氏链霉菌M40[1][2]中分离得到。

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 抗感染 >> 真菌

[体外研究]

除草剂A是迄今为止修饰最广泛的除草剂,它在C8处具有5-羟基丁炔基[1]。除草素生物合成的前体是D-葡萄糖、D-核糖、利索菌素和L-蛋氨酸[1]。除草剂是针对双子叶植物的选择性除草剂,并抑制大白菜和水稻种子的萌发[1]。除草剂可以保护水稻植株免受叶枯病的侵害,还具有抗真菌和抗真菌活性[1]。

[参考文献]

[1]. Lin GM, et al. Identification and Interrogation of the Herbicidin Biosynthetic Gene Cluster: First Insight into the Biosynthesis of a Rare Undecose Nucleoside Antibiotic. J Am Chem Soc. 2017 Nov 22;139(46):16450-16453.

[2]. Ha S, et al. Optimization of Herbicidin A Production in Submerged Culture of Streptomyces scopuliridis M40. J Microbiol Biotechnol. 2017 May 28;27(5):947-955.

除草素A物理化学性质

[ 分子式 ]:
C₂₃H₂₉N₅O₁₁

[ 分子量 ]:
551.50300

[ 精确质量 ]:
551.18600

[ PSA ]:
219.83000

[ 储存条件 ]:
-20°C，密闭，干燥

除草素A毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LV2630000

CAS REGISTRY NUMBER :: 55353-31-6

LAST UPDATED :: 199206

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C23-H29-N5-O11

MOLECULAR WEIGHT :: 551.57

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 29,863,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 5,305,1981