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菜豆苷

菜豆苷用途

芳樟醇是一种天然化合物,具有抗癌活性[1]。

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菜豆苷名称

[ CAS 号 ]:
554-35-8

[ 中文名 ]:
菜豆苷

[ 英文名 ]:
LINAMARIN

[中文别名 ]:

亚麻苷

[英文别名 ]:

Phaseolunatin
LINAMARIN

菜豆苷生物活性

[ 描述 ]:

芳樟醇是一种天然化合物,具有抗癌活性[1]。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Christopher Avwoghokoghene Idibie, et al. Cytotoxicity of purified cassava linamarin to a selected cancer cell lines. Bioprocess Biosyst Eng. 2007 Jul;30(4):261-9.

菜豆苷物理化学性质

[ 密度 ]:
1.41g/cm3

[ 沸点 ]:
473.3ºC at 760mmHg

[ 熔点 ]:
142-143ºC

[ 分子式 ]:
C₁₀H₁₇NO₆

[ 分子量 ]:
247.24500

[ 闪点 ]:
240ºC

[ 精确质量 ]:
247.10600

[ PSA ]:
123.17000

[ 折射率 ]:
1.549

[ 储存条件 ]:
-20°C，密闭，干燥

菜豆苷MSDS

菜豆苷毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TZ4850000

CHEMICAL NAME :: Propanenitrile, 2-(beta-D-glucopyranosyloxy)-2-methyl-

CAS REGISTRY NUMBER :: 554-35-8

BEILSTEIN REFERENCE NO. :: 0019237

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C10-H17-N-O6

MOLECULAR WEIGHT :: 247.28

WISWESSER LINE NOTATION :: T6OTJ BQ CQ DQ EQ FOX1&1&1CN

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - effect, not otherwise specified Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Gastrointestinal - hypermotility, diarrhea

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 42,539,1977 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 120 mg/kg

SEX/DURATION :: female 8 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :: TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 31,241,1985

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菜豆苷安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H315-H319-H332-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
20/22-36/37/38

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
TZ4850000

菜豆苷合成路线

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菜豆苷文献

Synthesis and Characterization of Hapten-Protein Conjugates for Antibody Production against Cyanogenic Glycosides.

J. Food Prot. 78 , 1408-13, (2015)

Consumption of cyanogenic plants can cause serious health problems for humans. The ability to detect and quantify cyanogenic glycosides, capable of generating cyanide, could contribute to prevention o...

A recycling pathway for cyanogenic glycosides evidenced by the comparative metabolic profiling in three cyanogenic plant species.

Biochem. J. 469 , 375-89, (2015)

Cyanogenic glycosides are phytoanticipins involved in plant defence against herbivores by virtue of their ability to release toxic hydrogen cyanide (HCN) upon tissue disruption. In addition, endogenou...

Overexpression of hydroxynitrile lyase in cassava roots elevates protein and free amino acids while reducing residual cyanogen levels.

PLoS ONE 6(7) , e21996, (2011)

Cassava is the major source of calories for more than 250 million Sub-Saharan Africans, however, it has the lowest protein-to-energy ratio of any major staple food crop in the world. A cassava-based d...

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菜豆苷